Research Article
Comparison of Two Waves of COVID-19 in Critically Ill Patients: A Retrospective Observational Study
Table 1
Comparison of patient characteristics, treatment, and outcomes between the two waves.
| | Total | First wave | Second wave | -value | | 241 | 185 |
| | Age (years) | 66 ± 15.75 | 70.4 ± 16.5 | 0.06 | | Under 40 | 16 | 9 | | 40–70 | 115 | 70 | | Above 70 | 110 | 106 | | Body mass index (BMI) (kg/m2) | 30.3 ± 7 | 29.3 ± 8.4 | 0.045 | | <18.5 | 3 | 9 | | | 18.5–24.9 | 52 | 56 | | 25–29.9 | 76 | 54 | | 30–34.9 | 58 | 33 | | 35–39.9 | 28 | 15 | | ≥40 | 24 | 18 | | African american (AA) race n (%) | 23 (10) | 15 (8) | 0.61 | | Females n (%) | 83 (34) | 79 (43) | 0.08 |
| | Past medical history n (%) | | Diabetes | 103 (43) | 72 (39) | 0.43 | | Hypertension | 160 (66) | 127 (69) | 0.62 | | Cardiovascular disease | 74 (31) | 92 (50) | <0.01 | | Chronic kidney disease | 31 (13) | 34 (18) | 0.12 |
| | COVID-19 directed treatment n (%) | | Remdesivir | 48 (20) | 136 (74) | <0.01 | | Dexamethasone | 13 (5) | 165 (89) | <0.01 | | Hydroxychloroquine | 190 (79) | 2 (1) | <0.01 | | Convalescent plasma | 41 (17) | 50 (27) | <0.01 |
| | Clinical outcomes n (%) | | Acute kidney injury (AKI) | 174 (72) | 116 (63) | 0.04 | | Renal replacement therapy (RRT) | 62 (36) | 35 (30) | 0.1 | | Mortality | 168 (70) | 117 (63) | 0.16 |
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