Predictive Factors, Treatment, and Outcomes of Coagulase-Negative Staphylococcal Peritonitis in Malaysian Peritoneal Dialysis Patients: A Single-Center Study
Table 4
Antimicrobial agents prescribed for CoNS peritonitis (N = 140).
Antibiotics
First peritonitis (N = 96)
Relapsed peritonitis (N = 15)
Repeat peritonitis (N = 29)
Overall (N = 140)
Empirical therapy
Definitive therapy
Empirical therapy
Definitive therapy
Empirical therapy
Definitive therapy
Empirical therapy
Definitive therapy
Gram-positive coverage
Cefazolin
65 (68%)
18 (19%)
3 (20%)
0
20 (69%)
7 (24%)
88 (63%)
25 (18%)
Cloxacillin
27 (28%)
24 (25%)
3 (20%)
2 (13%)
5 (17%)
3 (10%)
35 (25%)
29 (21%)
Vancomycin
2 (2%)
53 (55%)
8 (53%)
11 (74%)
4 (14%)
19 (66%)
14 (10%)
83 (59%)
Others
2 (2%)
1 (1%)
1 (7%)
2 (13%)
0
0
3 (2%)
3 (2%)
Gram-negative coverage
Ceftazidime
94 (98%)
NA
11 (73%)
NA
28 (97%)
NA
133 (95%)
NA
Aminoglycosides
Gentamicin
92 (96%)
81 (84%)
14 (93%)
14 (93%)
27 (93%)
25 (86%)
133 (95%)
120 (86%)
Amikacin
3 (3%)
12 (13%)
0
0
2 (7%)
3 (11%)
5 (4%)
15 (11%)
Not given
1 (1%)
3 (3%)
1 (7%)
1 (7%)
0
1 (3%)
2 (1%)
5 (3%)
Others include cefepime, linezolid, meropenem, piperacillin/tazobactam, rifampicin, and trimethoprim/sulfamethoxazole. NA, not applicable as ceftazidime was discontinued once CoNS was isolated from peritoneal dialysate samples.
