International Journal of Nephrology

Proteinuria: From Molecular to Clinical Applications in Glomerulonephritis


Publishing date
08 Jun 2012
Status
Published
Submission deadline
20 Jan 2012

Lead Editor

1D'Amico Foundation for Renal Diseases Research, Via Cherubini 6, 20100 Milan, Italy

2Department of Nephrology, Lund University, Lund, Sweden

3Section of Nephrology, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy


Proteinuria: From Molecular to Clinical Applications in Glomerulonephritis

Description

Primary Glomerulonephritis (GN) is still one of the main causes of progression to end-stage renal disease (ESRD) and contributes to the elevated costs for renal replacement therapies. The aetiology of the various types of GN is still largely unknown, and genetic, molecular, and cellular factors responsible of renal lesions are different between them. Proteinuria, besides being a marker of damage, is toxic to the kidney since it is associated with the development of tubule-interstitial damage and fibrosis; moreover, it is the main predictor of functional outcome and progression. Analysis of composition of proteinuria showed that some high-molecular-weight (HMW) proteins (IgG, IgM, α2-macroglobulin) and some low-molecular-weight (LMW) proteins (α1-microglobulins, β2-microglobulin) predict functional outcome better than proteinuria per day, but outcome prediction and therapy responsiveness should be improved. Recent analysis of urinary proteome identified patterns specific for some types of GN suggesting the possibility in the near future to diagnose GN without renal biopsy and improve outcome prediction and therapy responsiveness. The main goals of future research on urinary excretion of proteins, polypeptides, and proinflammatory and profibrotic molecules may be to improve assessment of mechanisms of renal damage; assess disease severity and activity; identify more powerful predictors of functional outcome and therapy responsiveness in individual patients; and evaluate the power of urinary proteome to assess diagnosis and predict outcomes and responsiveness to treatments. We invite investigators to contribute original research articles as well as review articles that stimulate the continuing efforts to understand the mechanisms of renal damage in GN and contribute to development of strategies to contrast progression. Potential topics include, but are not limited to:

  • Recent advances in mechanisms of proteinuria
  • Recent advances in proteomic analysis
  • Urinary molecular markers of renal damage and disease activity
  • Proteinuric patterns with predictive value of functional outcome
  • Urinary predictors of therapy responsiveness

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijn/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 424968
  • - Editorial

Proteinuria: From Molecular to Clinical Applications in Glomerulonephritis

Claudio Bazzi | Omran Bakoush | Loreto Gesualdo
  • Special Issue
  • - Volume 2012
  • - Article ID 749010
  • - Review Article

The Glomerular Filtration Barrier: Components and Crosstalk

Madhav C. Menon | Peter Y. Chuang | Cijiang John He
  • Special Issue
  • - Volume 2012
  • - Article ID 937623
  • - Review Article

An Overview of Molecular Mechanism of Nephrotic Syndrome

Juliana Reis Machado | Laura Penna Rocha | ... | Marlene Antônia Reis
  • Special Issue
  • - Volume 2012
  • - Article ID 546039
  • - Review Article

Understanding the Mechanisms of Proteinuria: Therapeutic Implications

Jorge E. Toblli | P. Bevione | ... | M. Angerosa
  • Special Issue
  • - Volume 2012
  • - Article ID 315467
  • - Research Article

Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy

M. Colleen Hastings | Sabahat Afshan | ... | Robert J. Wyatt
  • Special Issue
  • - Volume 2012
  • - Article ID 809456
  • - Review Article

Is the Antiproteinuric Effect of Cyclosporine A Independent of Its Immunosuppressive Function in T Cells?

Bin Zhang | Wei Shi
  • Special Issue
  • - Volume 2012
  • - Article ID 314251
  • - Review Article

Progress in Pathogenesis of Proteinuria

Aihua Zhang | Songming Huang
  • Special Issue
  • - Volume 2012
  • - Article ID 427060
  • - Review Article

Is There a Role for Mammalian Target of Rapamycin Inhibition in Renal Failure due to Mesangioproliferative Nephrotic Syndrome?

Hernán Trimarchi | Mariano Forrester | ... | Pablo Young
  • Special Issue
  • - Volume 2012
  • - Article ID 481520
  • - Review Article

Mechanisms of Glomerular Albumin Filtration and Tubular Reabsorption

Akihiro Tojo | Satoshi Kinugasa
  • Special Issue
  • - Volume 2012
  • - Article ID 146987
  • - Review Article

Urinary Markers of Glomerular Injury in Diabetic Nephropathy

Abraham Cohen-Bucay | Gautham Viswanathan
International Journal of Nephrology
 Journal metrics
Acceptance rate20%
Submission to final decision42 days
Acceptance to publication32 days
CiteScore2.600
Impact Factor-
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