International Journal of Nephrology

The Phosphorus and the Vascular Calcification in ESRD between Old Adventures and New Horizons


Publishing date
15 Sep 2011
Status
Published
Submission deadline
15 Mar 2011

1Department of Medicine; UOC of Nephrology, “A. Landolfi” Hospital, Via Melito snc, 83029 Solofra, Italy

2Medizinische Klinik III, Klinikum Coburn, Ketschendorfer Straße 33, 96450 Koburg, Germany

3Department of Nephrology and Urology, Federico II University, 80138 Naples, Italy

4Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong


The Phosphorus and the Vascular Calcification in ESRD between Old Adventures and New Horizons

Description

Cardiovascular disease is the main cause of morbidity and mortality in patients with end-stage renal disease (ESRD). The mechanisms underlying this increased risk are not clearly understood. The mechanisms involved in the connection between chronic cardiovascular disease and chronic kidney disease (CKD) are probably numerous. Phosphorus and vascular calcification can be considered the causal link between them. The association between vascular calcifications, inflammation, and atherosclerosis seems to be not a simple passive precipitation but a complex problem of the mineral metabolism in CKD. It has already been shown that vascular calcifications produce an increase in the rigidity of the vascular wall with deceleration of the progression of the pulse wave and alteration of its morphology. Increasing arterial stiffness contributes to increasing ventricular afterload, decreased sub-endocardial perfusion, and increased mechanical fatigue of arteries, resulting in chronic low-grade cardiac ischemia due to increased oxygen consumption and reduced diastolic coronary flow. In fact, serum concentrations of calcium and phosphate exceed the calcium-phosphate solubility product, but precipitation in the vasculature does not normally take place because of VC inhibitors. Human and mouse studies have revealed multiple local and systemic inhibitors which are associated with reduced vascular calcification. But phosphate is probably the predominant inducer of vascular calcification, and elevated serum levels are strongly associated with increased vascular calcification and mortality. So, we are back to phosphorus, reevaluating the effects and observing, at the light of new evidence (such as the FGF and Kloto), its importance in determining the link between CKD and Chronic Heart Disease. Potential topics include, but are not limited to:

  • Phosphate metabolism in CKD stages 3–5: dietary and pharmacological control
  • Phosphorus, FGF-23 and Kloto
  • Calcium-phosphorus and blood pressure in dialysis patients
  • Vitamin D and paracalcitol for ESRD and dialysis patients
  • Inflammation and vascular calcification
  • The new guidelines on KDIGO chronic kidney disease-mineral and bone disorders (CKD-BMDs): expectations, novelty, and confirmation

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijn/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 716526
  • - Editorial

The Phosphorus and the Vascular Calcification in ESRD between Old Adventures and New Horizons

Biagio Raffaele Di Iorio | Markus Ketteler | ... | Angela Wang
  • Special Issue
  • - Volume 2011
  • - Article ID 297070
  • - Clinical Study

Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation

Kathryn K. Stevens | Emily P. McQuarrie | ... | Alan G. Jardine
  • Special Issue
  • - Volume 2011
  • - Article ID 198045
  • - Review Article

Vascular and Valvular Calcification in Chronic Peritoneal Dialysis Patients

Angela Yee-Moon Wang
  • Special Issue
  • - Volume 2011
  • - Article ID 906832
  • - Review Article

Clinical Impact of Hypercalcemia in Kidney Transplant

Piergiorgio Messa | Cosimo Cafforio | Carlo Alfieri
  • Special Issue
  • - Volume 2011
  • - Article ID 758450
  • - Review Article

Effects of the Use of Non-Calcium Phosphate Binders in the Control and Outcome of Vascular Calcifications: A Review of Clinical Trials on CKD Patients

Piergiorgio Bolasco
  • Special Issue
  • - Volume 2011
  • - Article ID 516237
  • - Review Article

Endothelin but Not Angiotensin II May Mediate Hypertension-Induced Coronary Vascular Calcification in Chronic Kidney Disease

Simon W. Rabkin
  • Special Issue
  • - Volume 2011
  • - Article ID 939613
  • - Review Article

Association of Serum Phosphate and Related Factors in ESRD-Related Vascular Calcification

Cai-Mei Zheng | Kuo-Cheng Lu | ... | Yuh-Feng Lin
  • Special Issue
  • - Volume 2011
  • - Article ID 734832
  • - Review Article

Arterial Stiffness in Chronic Kidney Disease: The Usefulness of a Marker of Vascular Damage

Antonio Bellasi | Emiliana Ferramosca | Carlo Ratti
  • Special Issue
  • - Volume 2011
  • - Article ID 970245
  • - Review Article

Phosphate Metabolism in CKD Stages 3–5: Dietary and Pharmacological Control

Markus Ketteler
  • Special Issue
  • - Volume 2011
  • - Article ID 702406
  • - Case Report

Vascular Calcification in an Adolescent Treated with Long-Term Peritoneal Dialysis

Mesiha Ekim | Suat Fitoz | ... | Fatos Yalcinkaya
International Journal of Nephrology
 Journal metrics
Acceptance rate20%
Submission to final decision42 days
Acceptance to publication32 days
CiteScore2.600
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