Aberrant Methylation Inactivates Transforming Growth Factor 𝛽 Receptor I in Head and Neck Squamous Cell Carcinoma

Table 1

Relationship between clinicopathological features of HNSCC patients and 𝑇𝛽𝑅-𝐼gene promoter aberrant methylation.

	No. Patients (%)	Methylation (%)	P
All patients	50 (100)	31( 62)
Male	42 ( 84)	27 (64)
Female	8 (16)	4 (50)	0.450
Site
Oral Cavity	22 (44)	13 (59)
Oropharynx	5 (10)	4 (80)
Hypopharynx	6 (12)	3 (50)
Larynx	17 (34)	11 (65)	0.756
Tumor differentiation
Well differentiated	13 (26)	10 (76)
Mod. differentiated	30 (60)	19 (63)
Poorly differentiated	5 (19)	4 (80)	0.649
n.a.	2 ( 4)
Disease stage
I	4 ( 8)	3 (75)
II	7 (14)	5 (71)
III	13 (26)	8 (62)
IV	26 (52)	15 (57)	0.917
Median age (range), y	61.54 (38–84)

Abbreviation: na Not available.