Long-Term Histologic Changes in Nasal Mucosa after Total Laryngectomy

Table 2

The comparison of duration of time between laryngectomy and biopsy. Group1, less than 12 months, group 2, 12–36 months, group 3, more than 36 months. *In group 3, three patients have total atrophy; one patient has focal atrophy. In the other groups atrophy is focal. ^∗∗𝑃<.005.

Histopathologic changes	Groups
	Group 1 (𝑛 = 4)	Group 2 (𝑛 = 2)	Group 3 (𝑛 = 5)
Destruction of goblet cells	%50 (𝑛 = 2)	%100 (𝑛 = 2)	%100 (𝑛 = 5)
Fibrosis in stroma	%100 (𝑛 = 4)	%100 (𝑛 = 2)	%60 (𝑛 = 3)
Destruction of cilia	%50 (𝑛 = 2)	%50 (𝑛 = 1)	%60 (𝑛 = 3)
Destruction of glands	%25 (𝑛 = 1)	%25 (𝑛 = 1)	%60 (𝑛 = 3)
Atrophy	%75 (𝑛 = 3)	%50 (𝑛 = 1)	%80 (𝑛 = 4)*
Neovascularization	%50 (𝑛 = 2)	—	%40 (𝑛 = 2)
Congestion	%75 (𝑛 = 3)**	%50 (𝑛 = 1)**	—
Mixoid degeneration	%25 (𝑛 = 1)	%50 (𝑛 = 1)	%20 (𝑛 = 1)