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International Journal of Otolaryngology
Volume 2010, Article ID 424161, 8 pages
Research Article

Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs

1Department of Otolaryngology Head and Neck Surgery, Georgetown University Hospital, Washington, DC 20007, USA
2Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
3Department of Biostatistics, Georgetown University Medical Center, Washington, DC 20057, USA

Received 11 November 2009; Revised 17 March 2010; Accepted 27 March 2010

Academic Editor: Patrick James Bradley

Copyright © 2010 Neda Ahmadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We evaluated the chemopreventive effect of nonsteroidal anti-inflammatory drug (NSAID) use in head and neck squamous cell carcinomas (HNSCC) by conducting a case-control study based on the administration of a standardized questionnaire to 71 incident HNSCC cases and same number of healthy controls. NSAID use was associated with a 75% reduction in risk of developing HNSCC. A significant risk reduction was noted in association with frequency of NSAID use. Restricting the analysis to aspirin users revealed a significant 90% reduction in risk of developing HNSCC. This study provides evidence for a significant reduction in the risk of developing HNSCC in users of NSAIDs, and specifically aspirin users.