Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs
Table 2
Characteristics of cases and controls by NSAID use. Number (percentage) is shown unless otherwise indicated.
Cases
Controls
Never users ()
Ever users (N=46)
-value*
Never users ()
Ever users ()
-value*
Age, years mean (SD)
52
(12)
58
(11)
.02
54
(10)
58
(10)
.30
Smoking Status
.77
.68
Ever
20
(80)
35
(76)
7
(70)
48
(79)
Never
5
(20)
11
(24)
3
(30)
13
(21)
Pack-years
.54
.13
40
6
(30)
8
(23)
3
(43)
12
(25)
40–60
4
(20)
12
(34)
3
(43)
8
(17)
60
9
(45)
12
(34)
1
(14)
23
(48)
Unknown
1
(5)
3
(9)
0
(0)
5
(10)
Race
.40
.11
Caucasian
19
(76)
40
(87)
8
(80)
47
(77)
African American
5
(20)
4
(9)
0
(0)
10
(16)
Other
1
(4)
2
(4)
2
(20)
4
(7)
Alcohol Consumption
—
.55
Ever
25
(100)
46
(100)
9
(90)
56
(91)
Never
0
(0)
0
(0)
1
(10)
4
(7)
Unknown
0
(0)
0
(0)
0
(0)
1
(2)
Drink-years
.06
.53
20
4
(16)
14
(31)
3
(34)
13
(24)
20–40
10
(40)
7
(15)
3
(33)
10
(18)
40–60
1
(4)
8
(17)
1
(11)
8
(14)
60
9
(36)
15
(33)
1
(11)
17
(30)
Unknown
1
(4)
2
(4)
1
(11)
8
(14)
Current BMI, mean (SE)†
24
(1.1)
27
(0.8)
.08
28
(1.5)
28
(0.6)
.97
Married or living as married
.01
0.99
Yes
10
(40)
32
(70)
8
(80)
46
(75)
No
15
(60)
13
(28)
2
(20)
15
(25)
Unknown
0
(0)
1
(2)
0
(0)
0
(0)
Education level
.42
.99
College
15
(60)
23
(50)
2
(20)
15
(24)
College
10
(40)
23
(50)
8
(80)
45
(74)
Unknown
0
(0)
0
(0)
0
(0)
1
(2)
*
-values were computed using -tests for continuous characteristics, Fisher's exact test for categorical characteristics with cell frequencies of 5 or less, and chi-square tests for all other characteristics. Missing values were excluded from the -value computation. †BMI comparisons were age adjusted. Means are shown for a 56-year-old subject. Missing data: BMI unknown for 1 case and 1 control. SD: Standard Deviation; SE: Standard Error.
