International Journal of Otolaryngology / 2010 / Article / Tab 2 / Research Article
Ototoxicity from Combined Cisplatin and Radiation Treatment: An In
Vitro Study Table 2 Differential expression of apoptosis-related genes which have direct upstream or downstream relationship with p53 in each treatment group [irradiation (Gy), cisplatin (CDDP), or combination of both (Gy + CDDP)] when compared to nontreated control cells at 3 h, 24 h, and 72 h after treatment.
3 hours Symbol Gy CDDP Gy+CDDP Symbol Gy CDDP Gy+CDDP CCNG1 I I KLF6 D D D CDKN1A I I CCND1 D MDM2 I I CTCF D TP53INP1 I I IRS1 D BTG2 I ATF3 D DDX5 I AURKA D GDF15 I BID D IL6 I CCNB1 D C11ORF82 I CEBPB D CASP3 I DDR1 D CASP6 I ETS1 D CRYAB I FHL2 D HSP90AA1 I HBEGF D MED1 I HIPK1 D ZMAT3 I HSPB1 D MAPK3 D MCL1 D MYC D NR4A1 D OSGIN1 D PLK1 D PMEPA1 D PPP1R13L D THBS1 D THBS2 D YY1 D 24 hours Symbol Gy CDDP Gy+CDDP Symbol Gy CDDP Gy+CDDP CCNG1 I I I APEX1 D D CDKN1A I I I BHLHE40 D D EIF2AK2 I I I BRE D D RFC1 I I I PMEPA1 D D BUB1 I I S100A4 D D CCAR1 I I SERPINE1 D D CKAP2 I I SPP1 D D HSP90AA1 I I THBS2 D D MDM2 I I WWOX D D TOP2A I I SLC2A1 D TP53INP1 I I BTG1 D ZNF148 I I CAV1 D KLF6 I CEBPB D BLM I TIMP3 D BRCA1 I ATP1A1 D HMMR I CDK4 D IFI16 I CDKN2A D RAD54L I CDKN2C D RB1 I GSTM5 D TOP1 I ID2 D TOPBP1 I TFAP2A D TTK I BTG2 I C11ORF82 I FUBP1 I NFKB2 I NUPR1 I TOPORS I 72 hours Symbol Gy CDDP Gy+CDDP Symbol Gy CDDP Gy+CDDP ANXA1 I I I LGALS3 I AURKA I I I LIF I BUB1B I I I MAP2K3 I CAV1 I I I MMP2 I CCNB1 I I I MYO6 I CCND1 I I I NFKB1 I CCNG1 I I I PLAUR I CDC20 I I I PRKCA I CDKN1A I I I PTGS1 I CLU I I I SAT1 I DDIT4 I I I SERPINE2 I EGR1 I I I SLC2A1 I FOSL1 I I I SOD2 I GLIPR1 I I I TADA3L I HSPB1 I I I THBS2 I IER3 I I I TOPBP1 I INHBA I I I TSC2 I IRS1 I I I VDR I NFKBIA I I I FEN1 D D D PHLDA1 I I I GADD45A D D D PLK1 I I I JUN D D D PTGS2 I I I MCM2 D D D PTTG1 I I I NDRG1 D D D S100A4 I I I STAT1 D D D SERPINE1 I I I ATF3 D D SGK1 I I I PPP2R2A D D SPP1 I I I TP53BP2 D D THBS1 I I I CDK4 D D TMSB4X I I I FUBP1 D D UBE2C I I I GSK3B D D ZYX I I I HMGB1L1 D D BCL3 I I HSPA5 D D MMP3 I I PARK7 D D S100A6 I I PCNA D D ABCB1B I I PPP1R15A D D AKAP12 I I SMN1 D D ATM I I SP1 D D BID I I STMN1 D D BIRC5 I I XRCC6 D D BUB1 I I DAXX D I CCNA2 I I MX1 D I CCND3 I I PML D I CDC25C I I E2F1 D CKAP2 I I IFI16 D CRYAB I I BRE D CTSD I I CDC6 D DDR1 I I CHEK1 D DHCR24 I I COPS5 D EZR I I CTCF D FHL2 I I DDIT3 D FOS I I DUT D FOXM1 I I ELAVL1 D HMMR I I HOXA7 D IL6 I I HUWE1 D KAT2B I I KAT5 D KLF4 I I MAPK8 D MDM2 I I NME1 D MET I I RBBP6 D NEK2 I I TFAP2A D NQO1 I I TP53 D NQO2 I I VCAN D NR3C1 I I PLK3 I I PTPRA I I RAD54L I I S100A1 I I SHISA5 I I TACC3 I I TGFB2 I I TIMP3 I I TP53INP1 I I TTK I I YY1 I I ZMAT3 I I TXN I GDF15 I GSTM1 I RFWD2 I RRM2B I WRN I AFP I AHR I AP2A2 I BHLHE40 I C11ORF82 I CASP6 I CAT I CDK8 I CENPF I CFLAR I CSF2 I CX3CL1 I EPHA2 I ERCC3 I ERCC5 I ETS1 I FAS I FASN I GPI I HK2 I HSP90AB1 I ID1 I
