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International Journal of Otolaryngology
Volume 2011, Article ID 612690, 13 pages
Research Article

Reduced Formation of Oxidative Stress Biomarkers and Migration of Mononuclear Phagocytes in the Cochleae of Chinchilla after Antioxidant Treatment in Acute Acoustic Trauma

1Hough Ear Institute, Oklahoma City, OK 73112, USA
2Audiology and Speech-Language Pathology, College of Medical Sciences, Catholic University of Daegu, Kyungsansi, Republic of Korea
3Spatial Orientation Center, Naval Medical Center, San Diego, CA, USA
4Experimental Therapeutics Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
5Department of Otolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 72104, USA

Received 28 April 2011; Accepted 19 July 2011

Academic Editor: Daniel Bodmer

Copyright © 2011 Xiaoping Du et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Inhibition of inflammation and free radical formation in the cochlea may be involved in antioxidant treatment in acute acoustic trauma. Procedure. Chinchilla were exposed to 105 dB sound pressure level octave band noise for 6 hours. One group of chinchilla was treated with antioxidants after noise exposure. Auditory brainstem responses, outer hair cell counts, and immunohistochemical analyses of biomarkers in the cochlea were conducted. Results. The antioxidant treatment significantly reduced hearing threshold shifts, outer hair cell loss, numbers of CD45+ cells, as well as 4-hydroxy-2-nonenal and nitrotyrosine formation in the cochlea. Conclusion. Antioxidant treatment may provide protection to sensory cells by inhibiting formation of reactive oxygen and nitrogen products and migration of mononuclear phagocytes in the cochlea. The present study provides further evidence of effectiveness of antioxidant treatment in reducing permanent hearing loss.