p16, Cyclin D1, and HIF-1α Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy

Table 3

Univariate Cox regression analysis.

Variable	Locoregional control			Disease-free survival
	Hazard ratio	95% CI^*	𝑃 value	Hazard ratio	95% CI^*	𝑃 value
Age	0.992	0.934–1.054	0.796	1.054	1.018–1.090	0.003
Sex	0.497	0.063–3.950	0.509	1.831	0.809–4.147	0.147
Stage	1.004	0.384–2.622	0.994	0.851	0.518–1.398	0.524
Tobacco	32.13	0.073–14061	0.263	1.807	0.690–4.733	0.229
Alcohol	6.764	0.850–53.83	0.071	1.713	0.793–3.702	0.171
Chemotherapy	0.266	0.069–1.031	0.055	0.307	0.144–0.657	0.002
p16	0.105	0.022–0.497	0.005	0.155	0.070–0.341	0.000
Cyclin D1	2.368	1.071–5.237	0.033	1.831	1.247–2.688	0.002
HIF-1α (nuclear)	1.339	0.986–1.818	0.061	1.233	1.011–1.503	0.039
EGFR	3.236	0.880–11.90	0.077	1.971	0.809–4.798	0.135
Cyclophilin B	1.787	0.501–6.382	0.371	1.447	0.742–2.821	0.278
p21	1.679	0.751–3.754	0.206	1.235	0.802–1.901	0.338
HIF-1α (cytoplasmic)	0.910	0.601–1.377	0.655	0.941	0.743–1.192	0.615
Carbonic anhydrase (membranous)	1.075	0.888–1.303	0.458	0.991	0.869–1.130	0.890
Carbonic anhydrase (cytoplasmic)	0.659	0.307–1.413	0.284	0.969	0.763–1.231	0.797
Major vault protein	1.178	0.903–1.537	0.226	1.066	0.928–1.225	0.365

^*Confidence interval.