p16, Cyclin D1, and HIF-1α Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy

Table 5

Summary of survival results stratified by biomarker status.

Markers	𝑛	3-year LRC	3-year DFS	3-year OS
All Patients	106	89.7%	74.0%	77.7%
p16+	70	96.6%	88.9%	92.8%
p16−	36	75.4%	46.3%	49.8%
𝑃 value^§	0.001	<0.001	<0.001
EGFR+	27	85.0%	72.3%	82.3%
EGFR−	74	90.7%	74.5%	76.6%
𝑃 value^§	0.062	0.128	0.981
HIF-1α (nuclear)+	26	84.3%	67.6%	76.6%
HIF-1α (nuclear)−	32	100%	85.1%	90.1%
𝑃 value^§	0.019	0.093	0.328
Cyclin D1+	41	89.2%	67.8%	78.2%
Cyclin D1−	18	100%	94.1%	92.9%
𝑃 value^§	0.117	0.019	0.094

^§Log-rank test.