Clinical Outcomes of Gamma Knife Radiosurgery in the Treatment of Patients with Trigeminal Neuralgia

Table 4

Comparison studies.

Author, surgery type (year)	GKRS max dose (Gy)	Study endpoints	Surgery	GKRS	P value
		Initial actuarial pain-free rate	100%	78%	0.0002*
Linskey et al. [2], MVD (2008)	80–90	2-y actuarial pain-free rate	88%	50%
		5-y actuarial pain-free rate	80%	33%
		12-mo complete pain relief rate	68%	58%	0.089*
Brisman [40], MVD (2007)	75	18-mo complete pain relief rate	68%	24%
		Patients requiring retreatment	4.2%	18%	NS
		BNI Grade I-II classification	63%	56%	NR
Oh et al. [41], MVD (2008)	Mean: 77.8	Patients with pain recurrence	11.1%	11.1%	NR
		TN complexity grade	3	5.8	<0.001
Aryan et al. [42], MVD (2006)	90	Average response following treatment	3.4	2.4	0.017
		Patient satisfaction	8.7	6.4	0.02
Pollock and Schoeberl [43], PFE (2010)	Median: 85	1-y pain-free rate	84%	66%	0.003*
		4-y pain-free rate	77%	56%
		Retreatment rate	15%	35%	0.009
Pollock and Stein** [44], PFE (2010)	Median: 76.1	Patients treated with additional surgery	22%	48%	0.02

BNI: Barrow Neurological Institute; GKRS: Gamma Knife radiosurgery; MVD: microvascular decompression; NR: not reported; NS: nonsignificant; PFE: posterior fossa exploration; TN = trigeminal neuralgia.
^∗𝑃 value indicates overall pain-free levels.
**Data includes patients treated with ≥3 prior operations.