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International Journal of Otolaryngology
Volume 2013, Article ID 437815, 9 pages
http://dx.doi.org/10.1155/2013/437815
Clinical Study

HPV Prevalence and Prognostic Value in a Prospective Cohort of 255 Patients with Locally Advanced HNSCC: A Single-Centre Experience

1Department of Head and Neck Surgery, Centre Hospitalier de l’Université de Montréal, Hôpital Notre-Dame, 1560 Sherbrooke Est, Montreal (Quebec), Canada H2L 4M1
2Department of Radiation Oncology, Hôpital Maisonneuve-Rosemont, 5415 Boulevard de l'Assomption, Montréal (Quebec), Canada H1T 2M4
3Department of Microbiology, Centre Hospitalier de l’Université de Montréal, Hôpital Notre-Dame, 1560 Sherbrooke Est, Montreal (Quebec), Canada H2L 4M1
4Department of Radiation Oncology, Centre Hospitalier de l’Université de Montréal, Hôpital Notre-Dame, 1560 Sherbrooke Est, Montreal (Quebec), Canada H2L 4M1
5Department of Haematology and Medical Oncology, Centre Hospitalier de l’Université de Montréal, Hôpital Notre-Dame, 1560 Sherbrooke Est, Montreal (Quebec), Canada H2L 4M1
6Laboratoire de Biologie Moléculaire et Hématologie Spéciale, Département d’Hématologie, Hématologue et Oncologue Médical, Centre Hospitalier de l’Université de Montréal, Hôpital Notre-Dame, 1560 Sherbrooke Est, Montreal (Quebec), Canada H2L 4M1

Received 4 January 2013; Revised 28 March 2013; Accepted 28 March 2013

Academic Editor: David W. Eisele

Copyright © 2013 E. Thibaudeau et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. H. Westra, J. M. Taube, M. L. Poeta, S. Begum, D. Sidransky, and W. M. Koch, “Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck,” Clinical Cancer Research, vol. 14, no. 2, pp. 366–369, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Wiest, E. Schwarz, C. Enders, C. Flechtenmacher, and F. X. Bosch, “Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRB cell cycle control,” Oncogene, vol. 21, no. 10, pp. 1510–1517, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. H. C. Hafkamp, J. J. Manni, A. Haesevoets et al., “Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas,” International Journal of Cancer, vol. 122, no. 12, pp. 2656–2664, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Kumar, K. G. Cordell, J. S. Lee et al., “EGFR, p16, HPV titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer,” Journal of Clinical Oncology, vol. 26, no. 19, pp. 3128–3137, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. M. L. Gillison, W. M. Koch, R. B. Capone et al., “Evidence for a causal association between human papillomavirus and a subset of head and neck cancers,” Journal of the National Cancer Institute, vol. 92, no. 9, pp. 709–720, 2000. View at Google Scholar · View at Scopus
  6. C. T. Allen, J. S. Lewis Jr., S. K. El-Mofty, B. H. Haughey, and B. Nussenbaum, “Human papillomavirus and oropharynx cancer: biology, detection and clinical implications,” Laryngoscope, vol. 120, no. 9, pp. 1756–1772, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. K. Chaturvedi, E. A. Engels, W. F. Anderson, and M. L. Gillison, “Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States,” Journal of Clinical Oncology, vol. 26, no. 4, pp. 612–619, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. A. R. Kreimer, G. M. Clifford, P. Boyle, and S. Franceschi, “Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systemic review,” Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 2, pp. 467–475, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Hammarstedt, D. Lindquist, H. Dahlstrand et al., “Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer,” International Journal of Cancer, vol. 119, no. 11, pp. 2620–2623, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Näsman, P. Attner, L. Hammarstedt et al., “Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma?” International Journal of Cancer, vol. 125, no. 2, pp. 362–366, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Ramqvist and T. Dalianis, “Oropharyngeal cancer epidemic and human papillomavirus,” Emerging Infectious Diseases, vol. 16, no. 11, pp. 1671–1677, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. M. L. Gillison, G. D'Souza, W. Westra et al., “Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers,” Journal of the National Cancer Institute, vol. 100, no. 6, pp. 407–420, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. G. D'Souza, A. R. Kreimer, R. Viscidi et al., “Case-control study of human papillomavirus and oropharyngeal cancer,” The New England Journal of Medicine, vol. 356, no. 19, pp. 1944–1956, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Chen, L. M. Aaltonen, and A. Vaheri, “Human papillomavirus type 16 in head and neck carcinogenesis,” Reviews in Medical Virology, vol. 15, no. 6, pp. 351–363, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. C. C. R. Ragin and E. Taioli, “Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis,” International Journal of Cancer, vol. 121, no. 8, pp. 1813–1820, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Fakhry, W. H. Westra, S. Li et al., “Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial,” Journal of the National Cancer Institute, vol. 100, no. 4, pp. 261–269, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Fakhry and M. L. Gillison, “Clinical implications of human papillomavirus in head and neck cancers,” Journal of Clinical Oncology, vol. 24, no. 17, pp. 2606–2611, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. P. M. Weinberger, Z. Yu, B. G. Haffty et al., “Molecular classification identifies a subset of human papillomavirus- associated oropharyngeal cancers with favorable prognosis,” Journal of Clinical Oncology, vol. 24, no. 5, pp. 736–747, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. N. F. Schlecht, “Prognostic value of human papillomavirus in the survival of head and neck cancer patients: an overview of the evidence,” Oncology Reports, vol. 14, no. 5, pp. 1239–1247, 2005. View at Google Scholar · View at Scopus
  20. K. Lindel, K. T. Beer, J. Laissue, R. H. Greiner, and D. M. Aebersold, “Human papillomavirus positive squamous cell carcinoma of the oropharynx: a radiosensitive subgroup of head and neck carcinoma,” Cancer, vol. 92, pp. 805–813, 2001. View at Google Scholar
  21. S. R. Schwartz, B. Yueh, J. K. McDougall, J. R. Daling, and S. M. Schwartz, “Human papillomavirus infection and survival in oral squamous cell cancer: a population-based study,” Otolaryngology, vol. 125, no. 1, pp. 1–9, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. J. M. Ritchie, E. M. Smith, K. F. Summersgill et al., “Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx,” International Journal of Cancer, vol. 104, no. 3, pp. 336–344, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Dahlgren, H. Dahlstrand, D. Lindquist et al., “Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favorable prognostic factor in base of tongue cancer patients,” International Journal of Cancer, vol. 112, no. 6, pp. 1015–1019, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. M. L. Gillison, “Human papillomavirus and prognosis of oropharyngeal squamous cell carcinoma: implications for clinical research in head and neck cancers,” Journal of Clinical Oncology, vol. 24, no. 36, pp. 5623–5625, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Rischin, R. J. Young, R. Fisher et al., “Prognostic significance of p16INK4Aand human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial,” Journal of Clinical Oncology, vol. 28, no. 27, pp. 4142–4148, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. K. K. Ang, J. Harris, R. Wheeler et al., “Human papillomavirus and survival of patients with oropharyngeal cancer,” The New England Journal of Medicine, vol. 363, no. 1, pp. 24–35, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Coutlée, C. Hankins, and N. Lapointe, “Comparison between vaginal tampon and cervicovaginal lavage specimen collection for detection of human papillomavirus DNA by the polymerase chain reaction,” Journal of Medical Virology, vol. 51, no. 1, pp. 42–47, 1997. View at Publisher · View at Google Scholar
  28. F. Coutlée, D. Rouleau, P. Petignat et al., “Enhanced detection and typing of human papillomavirus (HPV) DNA in anogenital samples with PGMY primers and the linear array HPV genotyping test,” Journal of Clinical Microbiology, vol. 44, no. 6, pp. 1998–2006, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. M. V. Jacobs, A. M. de Roda Husman, A. J. C. van den Brule, P. J. F. Snijders, C. J. L. M. Meijer, and J. M. M. Walboomers, “Group-specific differentiation between high- and low-risk human papillomavirus genotypes by general primer-mediated PCR and two cocktails of oligonucleotide probes,” Journal of Clinical Microbiology, vol. 33, no. 4, pp. 901–905, 1995. View at Google Scholar · View at Scopus
  30. N. Reimers, H. U. Kasper, S. J. Weissenborn et al., “Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer,” International Journal of Cancer, vol. 120, no. 8, pp. 1731–1738, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. C. S. Kong, B. Narasimhan, H. Cao et al., “The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas,” International Journal of Radiation Oncology Biology Physics, vol. 74, no. 2, pp. 553–561, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. S. J. Smeets, A. T. Hesselink, E. J. M. Speel et al., “A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen,” International Journal of Cancer, vol. 121, no. 11, pp. 2465–2472, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. C. A. Fischer, I. Zlobec, E. Green et al., “Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality?” International Journal of Cancer, vol. 126, no. 5, pp. 1256–1262, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. N. F. Schlecht, R. D. Burk, L. Adrien et al., “Gene expression profiles in HPV-infected head and neck cancer,” Journal of Pathology, vol. 213, no. 3, pp. 283–293, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Specht, T. Richter, U. Müller, A. Walch, M. Werner, and H. Höfler, “Quantitative gene expression analysis in microdissected archival formalin-fixed and paraffin-embedded tumor tissue,” The American Journal of Pathology, vol. 158, no. 2, pp. 419–429, 2001. View at Google Scholar · View at Scopus
  36. R. L. Cantley, E. Gabrielli, F. Montebelli, D. Cimbaluk, P. Gattuso, and G. Petruzzelli, “Ancillary studies in determining human papillomavirus status of squamous cell carcinoma of the oropharynx: a review,” Pathology Research International, vol. 2011, Article ID 138469, 7 pages, 2011. View at Publisher · View at Google Scholar
  37. W. Shi, H. Kato, B. Perez-Ordonez et al., “Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma,” Journal of Clinical Oncology, vol. 27, no. 36, pp. 6213–6221, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. J. H. Maxwell, B. Kumar, F. Y. Feng et al., “Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence,” Clinical Cancer Research, vol. 16, no. 4, pp. 1226–1235, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. M. L. Gillison, Q. Zhang, R. Jordan et al., “Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer,” Journal of Clinical Oncology, vol. 30, no. 17, pp. 2102–2111, 2012. View at Publisher · View at Google Scholar
  40. D. J. Adelstein, Y. Li, G. L. Adams et al., “An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer,” Journal of Clinical Oncology, vol. 21, no. 1, pp. 92–98, 2003. View at Google Scholar · View at Scopus
  41. J. P. Pignon, A. L. Maître, E. Maillard, and J. Bourhis, “Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients,” Radiotherapy and Oncology, vol. 92, no. 1, pp. 4–14, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. A. A. Forastiere, H. Goepfert, and M. Maor, “Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer,” The New England Journal of Medicine, vol. 349, pp. 2091–2098, 2003. View at Google Scholar · View at Scopus