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International Journal of Otolaryngology
Volume 2013 (2013), Article ID 672621, 7 pages
Research Article

Sinonasal Cancer and Occupational Exposure in a Population-Based Registry

1Department of Preventive Medicine, Fondazione IRCCS Ca’ Granda—Ospedale Maggiore Policlinico, Via San Barnaba 8, 20122 Milan, Italy
2National Heart & Lung Institute, Department of Occupational & Environmental Medicine, Imperial College London, London SW3 6LR, UK
3Department of Clinical Science and Community Health, Università Degli Studi di Milano, Via San Barnaba 8, 20122 Milan, Italy

Received 7 June 2013; Accepted 19 July 2013

Academic Editor: Peter S. Roland

Copyright © 2013 Carolina Mensi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We examined occupational exposures among subjects with sinonasal cancer (SNC) recorded in a population-based registry in the Lombardy Region, the most populated and industrialized Italian region. The registry collects complete clinical information and exposure to carcinogens regarding all SNC cases occurring in the population of the region. In the period 2008–2011, we recorded 210 SNC cases (137 men, 73 women). The most frequent occupational exposures were to wood (44 cases, 21.0%) and leather dust (29 cases, 13.8%), especially among men: 39 cases (28.5%) to wood and 23 cases (16.8%) to leather dust. Exposure to other agents was infrequent (<2%). Among 62 subjects with adenocarcinoma, 50% had been exposed to wood dust and 30.7% to leather dust. The proportions were around 10% in subjects with squamous cell carcinoma and about 20% for tumors with another histology. The age-standardized rates (×100,000 person-years) were 0.7 in men and 0.3 in women. Complete collection of cases and their occupational history through a specialized cancer registry is fundamental to accurately monitor SNC occurrence in a population and to uncover exposure to carcinogens in different industrial sectors, even those not considered as posing a high risk of SNC, and also in extraoccupational settings.