Table of Contents Author Guidelines Submit a Manuscript
International Journal of Otolaryngology
Volume 2015, Article ID 708475, 8 pages
http://dx.doi.org/10.1155/2015/708475
Research Article

More Than One Disease Process in Chronic Sinusitis Based on Mucin Fragmentation Patterns and Amino Acid Analysis

1Department of Otolaryngology, Mansoura University Hospital, Mansoura University, Mansoura 35516, Egypt
2Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

Received 18 October 2014; Accepted 14 December 2014

Academic Editor: Ludger Klimek

Copyright © 2015 Mahmoud El-Sayed Ali and Jeffrey P. Pearson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. S. Ali and J. P. Pearson, “Upper airway mucin gene expression: a review,” Laryngoscope, vol. 117, no. 5, pp. 932–938, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Lang, G. C. Hansson, and T. Samuelsson, “Gel-forming mucins appeared early in metazoan evolution,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 41, pp. 16209–16214, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. M. E.-S. Ali, “Nasosinus mucin expression in normal and inflammatory conditions,” Current Opinion in Allergy and Clinical Immunology, vol. 9, no. 1, pp. 10–15, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Hijikata, I. Matsushita, G. Tanaka et al., “Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis,” Human Genetics, vol. 129, no. 2, pp. 117–128, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. M. S. Ali, J. A. Wilson, and J. P. Pearson, “Mixed nasal mucus as a model for sinus mucin gene expression studies,” Laryngoscope, vol. 112, no. 2, pp. 326–331, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. M. S. Ali, D. A. Hutton, J. A. Wilson, and J. P. Pearson, “Major secretory mucin expression in chronic sinusitis,” Otolaryngology—Head and Neck Surgery, vol. 133, no. 3, pp. 423–428, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Viswanathan, I. A. Brownlee, J. P. Pearson, and S. Carrie, “MUC5B secretion is up-regulated in sinusitis compared with controls,” American Journal of Rhinology, vol. 20, no. 5, pp. 554–557, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. Q. D. Guo and Q. Z. Chun, “The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis,” The American Journal of Rhinology, vol. 21, no. 3, pp. 359–366, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Xue-Kun, L. Yuan, Y. Jin, L. Peng, and L. Hong, “Expression of MUC2 and MUC5B in ethmoid sinus mucosa of patients with chronic rhinosinusitis,” Scientific Research and Essays, vol. 5, no. 13, pp. 1690–1696, 2010. View at Google Scholar · View at Scopus
  10. S. Carrie, D. A. Hutton, J. P. Birchall, G. G. Green, and J. P. Pearson, “Otitis media with effusion: components which contribute to the viscous properties,” Acta Oto-Laryngologica, vol. 112, no. 3, pp. 504–511, 1992. View at Publisher · View at Google Scholar · View at Scopus
  11. J. K. Sheehan, D. J. Thornton, M. Somerville, and I. Carlstedt, “Mucin structure: the structure and heterogeneity of respiratory mucus glycoproteins,” The American Review of Respiratory Disease, vol. 144, no. 3, pp. S4–S9, 1991. View at Google Scholar · View at Scopus
  12. D. J. Thornton, P. L. Devine, C. Hanski, M. Howard, and J. K. Sheehan, “Identification of two major populations of mucins in respiratory secretions,” American Journal of Respiratory and Critical Care Medicine, vol. 150, no. 3, pp. 823–832, 1994. View at Publisher · View at Google Scholar · View at Scopus
  13. J. R. Davies, N. Svitacheva, L. Lannefors, R. Kornfält, and I. Carlstedt, “Identification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions,” Biochemical Journal, vol. 344, no. 2, pp. 321–330, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. J. F. Forstner and G. G. Forstner, “Gastrointestinal mucus,” in Physiology of the Gastrointestinal Tract, L. R. Johnson, Ed., pp. 1255–1283, Raven Press, New York, NY, USA, 1994. View at Google Scholar
  15. V. Shankar, M. S. Gilmore, R. C. Elkins, and G. P. Sachdev, “A novel human airway mucin cDNA encodes a protein with unique tandem-repeat organization,” Biochemical Journal, vol. 300, no. 2, pp. 295–298, 1994. View at Google Scholar · View at Scopus
  16. S. J. Gendler and A. P. Spicer, “Epithelial mucin genes,” Annual Review of Physiology, vol. 57, pp. 607–634, 1995. View at Publisher · View at Google Scholar · View at Scopus
  17. D. W. Kennedy, “Prognostic factors, outcomes and staging in ethmoid sinus surgery,” The Laryngoscope, vol. 102, no. 12, pp. 1–18, 1992. View at Google Scholar · View at Scopus
  18. V. J. Lund, H. J. Neijens, P. A. R. Clement, R. Lusk, and H. Stammberger, “The treatment of chronic sinusitis: a controversial issue,” International Journal of Pediatric Otorhinolaryngology, vol. 32, supplement, pp. S21–S35, 1995. View at Publisher · View at Google Scholar · View at Scopus
  19. B. J. Starkey, D. Snary, and A. Allen, “Characterization of gastric mucoproteins isolated by equilibrium density gradient centrifugation in caesium chloride,” Biochemical Journal, vol. 141, no. 3, pp. 633–639, 1974. View at Google Scholar · View at Scopus
  20. J. E. Carlton and W. T. Morgan, “Simple, economical amino acid analysis based on pre-column derivatisation with 9-fluorenylmethyl chloroformate (FMOC),” in Techniques in Protein Chemistry, T. E. Hugli, Ed., pp. 226–270, Academic Press, New York, NY, USA, 1989. View at Google Scholar
  21. F. J. J. Fogg, D. A. Hutton, K. Jumel, J. P. Pearson, S. E. Harding, and A. Allen, “Characterization of pig colonic mucins,” Biochemical Journal, vol. 316, no. 3, pp. 937–942, 1996. View at Google Scholar · View at Scopus
  22. D. A. Hutton, L. Guo, J. P. Birchall, T. L. Severn, and J. P. Pearson, “MUC5B expression in middle ear mucosal glands,” Biochemical Society Transactions, vol. 26, no. 2, article S117, 1998. View at Google Scholar · View at Scopus
  23. J. Shinogi, T. Harada, T. Nonoyama, C. Kishioka, Y. Sakakura, and Y. Majima, “Quantitative analysis of mucin and lectin in maxillary sinus fluids in patients with acute and chrome sinusitis,” Laryngoscope, vol. 111, no. 2, pp. 240–245, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. B. J. Rankin, E. D. Srivastava, C. O. Record, J. P. Pearson, and A. Allen, “Patients with ulcerative colitis have reduced mucin polymer content in the adherent colonic mucus gel,” Biochemical Society Transactions, vol. 23, no. 1, p. 104S, 1995. View at Google Scholar · View at Scopus
  25. J. L. Newton, N. Jordan, L. Oliver et al., “Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised,” Gut, vol. 43, no. 4, pp. 470–475, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. I. Carlstedt, H. Lindgren, J. K. Sheehan, U. Ulmsten, and L. Wingerup, “Isolation and characterization of human cervical-mucus glycoproteins,” Biochemical Journal, vol. 211, no. 1, pp. 13–22, 1983. View at Google Scholar · View at Scopus
  27. D. J. Thornton, M. Howard, N. Khan, and J. K. Sheehan, “Identification of two glycoforms of the MUC5B mucin in human respiratory mucus. Evidence for a cysteine-rich sequence repeated within the molecule,” Journal of Biological Chemistry, vol. 272, no. 14, pp. 9561–9566, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Marriott and I. W. Kellaway, “The effect of tetracyclines on the viscoelastic properties of bronchial mucus,” Biorheology, vol. 12, no. 6, pp. 391–395, 1975. View at Google Scholar · View at Scopus
  29. D. J. Thornton, I. Carlstedt, M. Howard, P. L. Devine, M. R. Price, and J. K. Sheehan, “Respiratory mucins: identification of core proteins and glycoforms,” Biochemical Journal, vol. 316, no. 3, pp. 967–975, 1996. View at Google Scholar · View at Scopus
  30. D. A. Hutton, F. J. J. Fogg, H. Kubba, J. P. Birchall, and J. P. Pearson, “Heterogeneity in the protein cores of mucins isolated from human middle ear effusions: evidence for expression of different mucin gene products,” Glycoconjugate Journal, vol. 15, no. 3, pp. 283–291, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Herrmann, J. R. Davies, G. Lindell et al., “Studies on the ‘insoluble’ glycoprotein complex from human colon: identification of reduction-insensitive MUC2 oligomers and C-terminal cleavage,” The Journal of Biological Chemistry, vol. 274, no. 22, pp. 15828–15836, 1999. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Dekker, P. H. Aelmans, and G. J. Strous, “The oligomeric structure of rat and human gastric mucins,” Biochemical Journal, vol. 277, no. 2, pp. 423–427, 1991. View at Google Scholar · View at Scopus