Table of Contents Author Guidelines Submit a Manuscript
International Journal of Otolaryngology
Volume 2017, Article ID 5185268, 5 pages
https://doi.org/10.1155/2017/5185268
Research Article

Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss

1Otolaryngology Department, Hospital Vall d’Hebron, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain
2Biomedical Research in Cancer Stem Cells, Pathology Department, Hospital Vall d’Hebron, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain
3Oncology Department, Hospital Vall d’Hebron, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain
4Anaesthesiology and Resuscitation Department, Hospital Vall d’Hebron, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain
5Group of Mitochondrial Dysfunction and Diseases, International Clinical Research Center and St. Anne’s University Hospital Brno, Brno, Czech Republic

Correspondence should be addressed to J. Lorente; ten.norbehv@etnerolj

Received 23 January 2017; Revised 1 May 2017; Accepted 18 May 2017; Published 3 July 2017

Academic Editor: Leonard P. Rybak

Copyright © 2017 D. Graterol et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Many drugs used for cancer chemotherapy produce reactive oxygen species, thus leading to various complications including nephrotoxicity, cardiotoxicity, and ototoxicity. Objective. We have provided a haplogroup analysis of a cohort of cancer patients treated with chemotherapy and compared factors associated with associated hearing loss. Study Design and Methods. This observational cohort study includes a pure-tone audiometry of the patients who underwent chemotherapeutic treatment. Medical history, presence of risk factors for hearing loss, toxic habits, and association with haplogroups have been determined. Results. 40% of patients developed hearing loss after administration of cisplatin, which was bilateral and symmetrical and of high frequencies. The most frequent haplogroup was H with a slight overexpression of groups V and K and a low frequency of groups J and T. No association of the haplogroup types with the hearing loss has been found; however age was revealed as an important determining factor. Conclusions. Ototoxicity caused by cisplatin is manifested as bilateral, symmetrical, and predominantly high frequency hearing loss. Although we did not find a strong correlation of haplogroups with ototoxicity, our results revealed the existence of a risk group of elderly patients over 60, which are more susceptible to hearing loss induced by cisplatin, than young adults, regardless of preexisting hearing loss.