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Molecular mechanisms of photosensitization induced by drugs XIV: Two different behaviours in the photochemistry and photosensitization of antibacterials containing a fluoroquinolone like chromophore
G. De Guidi,1 S. Giuffrida
,1 S. Monti,2 P. S. Pisu,1 S. Sortino,1 and L. L. Costanzo11Dipartimento di Scienze Chimiche, Università di Catania, Viale A.Doria 8, Catania 95125, Italy
2Istituto di Fotochimica e Radiazioni d'Alta Energia del CNR, Area della Ricerca, Via P.Gobetti 101, Bologna 40129, Italy
Abstract
This paper deals with the photosensitizing activity of FLQs towards two different biosubstrates,
membrane and DNA. The in vitro phototoxic activity of these drugs vs. DNA presents peculiar features
with respect to that vs. membranes, probably due to a specific binding of the drugs to the double helix
and to the operativeness of different photosensitization mechanisms with the two types of biosubstrates.
A description of the UVA photochemistry and the photosensitizing properties of two significant examples
in the FLQ family is reported. The investigated compounds are Enoxacin, 1-ethyl-6-fluoro-1,4-dihydro-4-
oxo-7-[1-piperazinyl]-1,8-naphtyridine-3-carboxilic acid and Rufloxacin, 9-fluoro-2,3-dihydro-10-4´-methyl-
1´-piperazinyl-7-oxo-7H-pyrido
Copyright
Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
