Low-Dose UVA Radiation-Induced Adaptive Response in Cultured Human Dermal Fibroblasts
Figure 3
Ultrastructural changes of cultured fibroblasts. (a) SIG, normal morphology of fibroblast showed rich microvilli on cell surface (SEM). (b) HDG, 30 min after irradiation by 86.4 J/cm2 UVA, microvilli disappeared on cell surface (SEM). (c) ARG3, preirradiated with repetitive irradiation of 7.2 J/cm2 UVA for a total dosage of 28.8 J/cm2; 30 min after irradiation by 86.4 J/cm2 UVA, fibroblasts showed apoptosis (SEM). (d) SIG, normal morphology of fibroblast showed normal mitosis (TEM). (e) HDG, 30 min after irradiation by 86.4 J/cm2 UVA, cells with vacuolization showed necrosis (TEM). (f) ARG3, preirradiated with repetitive irradiation of 7.2 J/cm2 UVA with a cumulative dosage of 28.8 J/cm2, and then 30 min after irradiation by 86.4 J/cm2 UVA, fibroblasts showed apoptosis (TEM). (g) LDG3, after irradiation with repetitive irradiation of 7.2 J/cm2 UVA for a cumulative dosage of 28.8 J/cm2, fibroblasts showed plenty of RER (TEM). (h) LDG3, after irradiation with repetitive irradiation of 7.2 J/cm2 UVA for a cumulative dosage 28.8 J/cm2, fibroblasts showed increased number of mitochondria (TEM). (i) LDG5, after irradiation with repetitive irradiation of 7.2 J/cm2 UVA for a cumulative dosage 115.2 J/cm2, fibroblasts showed aging of mitochondria (TEM).
