Low-Dose UVA Radiation-Induced Adaptive Response in Cultured Human Dermal Fibroblasts

Table 4

Effects of low-dose UVA preirradiation on fibroblast DNA damage (𝑥±𝑆,𝑛=4).

Groups		The percentage of DNA migration (%)	𝑡 value	Average length of DNA migration (μm)	𝑡 value
SIG		7.50 ± 1.29		11.8 ± 3.49
HDG		90.8 ± 4.35^●●	−36.41	102 ± 29.4^●●	−11.98
ARG (J/cm^2)	7.2	82.5 ± 6.81^∆	3.794	88.4 ± 19.1	1.596
	14.4	75.0 ± 2.94^∆	10.97	77.3 ± 19.6^∆	12.78
	28.8	68.5 ± 3.87^∆∆	11.52	65.3 ± 18.5^∆∆	14.38
	57.6	57.9 ± 5.38^∆	8.568	49.3 ± 14.5^∆∆	16.76
	115.2	51.0 ± 5.48^∆	10.93	42.9 ± 11.4^∆∆	17.90

𝑡-test, compared with SIG, differences were extremely significant ^●●𝑃<0.001; compared with HDG, differences were extremely significant ^∆∆𝑃<0.001, and significant ^∆𝑃<0.01; linear regression analysis of internal ARG, the percentage of DNA migration (𝑟=0.764, 𝐹=25.25, 𝑡=−5.025, and 𝑃<0.001) and average length of DNA migration (𝑟=0.603, 𝐹=44.55, 𝑡=−6.674, and 𝑃<0.001) were both close related to accumulated doses.
One-way ANOVA, the percentage of DNA migration, and the average length of DNA migration were no different among the ARG1 (7.2 J/cm²), ARG2 (14.4 J/cm²), and ARG3 (28.8 J/cm²), 𝑃>0.05; 𝑡-test, there also was no difference between ARG4 (57.6 J/cm²) and ARG3 (115.2 J/cm²), 𝑃>0.05.