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International Journal of Photoenergy
Volume 2012 (2012), Article ID 646845, 8 pages
Research Article

Inhibitory Effects of Far-Infrared Irradiation Generated by Ceramic Material on Murine Melanoma Cell Growth

1Department of Radiology, School of Medicine, Taipei Medical University and Hospital, Taipei 110, Taiwan
2Department of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 433, Taiwan
3Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan
4Department of Biological Science and Technology, I-Shou University, Kaohsiung 824, Taiwan

Received 20 April 2011; Revised 9 July 2011; Accepted 9 July 2011

Academic Editor: Rodica-Mariana Ion

Copyright © 2012 Ting-Kai Leung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The biological effects of specific wavelengths, so-called “far-infrared radiation” produced from ceramic material (cFIR), on whole organisms are not yet well understood. In this study, we investigated the biological effects of cFIR on murine melanoma cells (B16-F10) at body temperature. cFIR irradiation treatment for 48 h resulted in an 11.8% decrease in the proliferation of melanoma cells relative to the control. Meanwhile, incubation of cells with cFIR for 48 h significantly resulted in 56.9% and 15.7% decreases in the intracellular heat shock protein (HSP)70 and intracellular nitric oxide (iNO) contents, respectively. Furthermore, cFIR treatment induced 6.4% and 12.3% increases in intracellular reactive oxygen species stained by 5-(and 6)-carboxyl- , -dichlorodihydrofluorescein diacetate and dihydrorhodamine 123, respectively. Since malignant melanomas are known to have high HSP70 expression and iNO activity, the suppressive effects of cFIR on HSP70 and NO may warrant future interest in antitumor applications.