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International Journal of Photoenergy
Volume 2012, Article ID 759205, 9 pages
http://dx.doi.org/10.1155/2012/759205
Research Article

Influence of the Human Skin Tumor Type in Photodynamic Therapy Analysed by a Predictive Model

Applied Optical Techniques Group, TEISA Department, University of Cantabria, Avenida de los Castros S/N, 39005 Santander, Spain

Received 29 July 2011; Accepted 26 September 2011

Academic Editor: David Worrall

Copyright © 2012 I. Salas-García et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Photodynamic Therapy (PDT) modeling allows the prediction of the treatment results depending on the lesion properties, the photosensitizer distribution, or the optical source characteristics. We employ a predictive PDT model and apply it to different skin tumors. It takes into account optical radiation distribution, a nonhomogeneous topical photosensitizer spatial temporal distribution, and the time-dependent photochemical interaction. The predicted singlet oxygen molecular concentrations with varying optical irradiance are compared and could be directly related with the necrosis area. The results show a strong dependence on the particular lesion. This suggests the need to design optimal PDT treatment protocols adapted to the specific patient and lesion.