Significant Inhibition of Tumor Growth following Single Dose Nanoparticle-Enhanced Photodynamic Therapy
Figure 5
(a) 29-day comparative PDT efficacy studies of MDA-MB-231 s.c. xenograft nude mouse model subjected to a single intratumoral injection of (i) saline without photoirradiation (black squares), (ii) saline with photoirradiation (red circles), (iii) PdTPP with photoirradiation (green upward-pointing triangles), and (iv) MSN-PdTPP with photoirradiation (blue downward-pointing triangles)—showing MSN-PdTPP to be highly efficacious in tumor reduction. Datapoints denote mean of twelve mice per group. (b) Photographs of tumors harvested from mice 28 days after treatment with (A) saline (control), (B) PdTPP, and (C) MSN-PdTPP, all subjected to photoirradiation (scale bar: 1 cm).
