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International Journal of Photoenergy
Volume 2014, Article ID 378673, 4 pages
http://dx.doi.org/10.1155/2014/378673
Research Article

Fluorescence Diagnostics of Colon Malignant and Premalignant Lesions Using 5-Aminolevulinic Acid

1P. A. Herzen Moscow Cancer Research Institute, 2nd Botkinskiy Proezd 3, Moscow 125284, Russia
2Department of Endoscopy, Russian Medical Academy for Postgraduate Training, 2nd Botkinskiy Proezd 5, Moscow 125284, Russia

Received 8 November 2013; Accepted 26 December 2013; Published 5 February 2014

Academic Editor: Victor Loschenov

Copyright © 2014 Elena V. Filonenko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Improvement of colon cancer diagnosis is a very important medical problem. Methods of fluorescence diagnosis (FD) with 5-aminolevulinic acid (5-ALA) have been used in detection of early cancer on the surface of mucosa. The objective of the study was to estimate the effectiveness of FD with 5-ALA in the detection of malignant lesions in the colon. From 2008 to 2010 full examinations have been performed in 78 patients suffering from colon polyps. For the study we used drug Alasens based on 5-ALA. Fluorescence colonoscopy with Alasens was made using the visual assessment of fluorescence images in combination with local fluorescence spectroscopy. The results of FD were compared with those of final histopathological study. The application of the method during colonoscopy allows specifying diagnosis, identifying areas of colon tumors transformation, and also showing a place for targeted biopsy. Sensitivity and specificity of FD with Alasens were 94.9% and 62.5%, respectively. The application of local fluorescence spectroscopy as a step of the combined approach allows increasing the specificity of fluorescence colonoscopy from 62.5% up to 93.7%.