Multiorganelle Localization of Metallated Phthalocyanine Photosensitizer in Colorectal Cancer Cells (DLD-1 and CaCo-2) Enhances Efficacy of Photodynamic Therapy
FITC Annexin V staining was used for the assessment of cell death mode in DLD-1 (a) and CaCo-2 (b) cells. Significant differences as compared to untreated cells are shown as ***. After 24 h, there was a significant increase in the percentage of apoptotic cell population compared to 1 h incubation in PDT treated DLD-1 cells (a). PDT treated CaCo-2 cells (b) had a significantly increased apoptotic population percentage after both 1 and 24 h incubation compared to their respective viable or necrotic cell population percentage ().
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