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International Journal of Photoenergy
Volume 2014, Article ID 471764, 9 pages
Research Article

Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles

1Department of Physics, Ryerson University, 350 Victoria Street, Toronto, ON, Canada M5B 2K3
2Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul Gordan Strasse 6, D-91052 Erlangen, Germany

Received 20 December 2013; Revised 15 February 2014; Accepted 2 March 2014; Published 2 April 2014

Academic Editor: Victor Loschenov

Copyright © 2014 Homa Assadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In imaging, contrast agents are utilized to enhance sensitivity and specificity of diagnostic modalities. In ultrasound imaging, microbubbles (MBs)—a gas-core shell-encapsulated agent—are used clinically as contrast agents. The working hypothesis of this study is that microbubbles can be employed as an intravascular contrast agent in optical imaging systems. In this work, the interaction of light and microbubbles in a turbid medium (intralipid) was investigated, particularly, the effect of MBs on the reduced scattering and absorption coefficients. Diffuse reflectance (DR) and total transmittance (TT) measurements of highly scattering intralipid suspension (0.5–5%) were measured using spectroscopic integrating sphere system in the absence and presence of Definity microbubbles. The optical properties were computed using the inverse adding doubling (IAD) software. The presence of microbubbles increased DR and decreased TT of intralipid phantoms. In the presence of MBs (0.5% volume concentration), the reflectance of the intralipid phantom increased from 35% to 100%. The reduced scattering coefficient increased significantly (30%) indicating potential use of MBs as optical contrast agents in light based modalities.