Potential Use of C₆₀/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer

Figure 6

Photodynamic effects of C₆₀/HP-β-CyD nanoparticles on tumor growth (a). Appearances of tumor (b) and changes in body weight (c) after intratumor injection to the tumor-bearing mice plus light irradiation. Black filled circle: saline; black filled square: C₆₀/HP-β-CyD; empty triangle: saline plus light irradiation (63 J/cm²); shadowed circle: C₆₀/HP-β-CyD (0.4 mg/kg) plus light irradiation (63 J/cm²); empty circle: C₆₀/HP-β-CyD (2.0 mg/kg) plus light irradiation (63 J/cm²). Each point represents the mean ± S.E. of 6–9 experiments. ^∗𝑃<0.05 versus saline. ^†𝑃<0.05 versus saline plus light irradiation. ^‡𝑃<0.05 versus C₆₀/HP-β-CyD (0.4 mg/kg) plus light irradiation (63 J/cm²).

(a)

(b)

(c)