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International Journal of Photoenergy
Volume 2014 (2014), Article ID 904304, 8 pages
Review Article

Microenvironment Dependent Photobiomodulation on Function-Specific Signal Transduction Pathways

1Laboratory of Laser Sports Medicine, South China Normal University, University Town, Guangzhou 510006, China
2Department of Chemistry and Biology, College of Science, National University of Defense Technology, Changsha 410073, China
3MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China

Received 7 January 2014; Accepted 28 January 2014; Published 9 March 2014

Academic Editor: Quan-Guang Zhang

Copyright © 2014 Timon Cheng-Yi Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cellular photobiomodulation on a cellular function has been shown to be homeostatic. Its function-specific pathway mechanism would be further discussed in this paper. The signal transduction pathways maintaining a normal function in its function-specific homeostasis (FSH), resisting the activation of many other irrelative signal transduction pathways, are so sparse that it can be supposed that there may be normal function-specific signal transduction pathways (NSPs). A low level laser irradiation or monochromatic light may promote the activation of partially activated NSP and/or its redundant NSP so that it may induce the second-order phase transition of a function from its dysfunctional one far from its FSH to its normal one in a function-specific microenvironment and may also induce the first-order functional phase transition of the normal function from low level to high level.