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International Journal of Photoenergy
Volume 2015, Article ID 148964, 12 pages
Review Article

Water-Solubilization of P(V) and Sb(V) Porphyrins and Their Photobiological Application

1Department of Applied Chemistry, Faculty of Engineering, University of Miyazaki, Gakuen-Kibanadai, Miyazaki 889-2192, Japan
2Department of Applied Chemistry and Biochemical Engineering, Graduate School of Engineering, Shizuoka University, Johoku 3-5-1, Hamamatsu, Shizuoka 432-8561, Japan

Received 25 September 2014; Revised 25 December 2014; Accepted 8 January 2015

Academic Editor: Maria da Graça P. Neves

Copyright © 2015 Jin Matsumoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Porphyrins have been widely utilized as biochemical and biological functional chromophores which can operate under visible-light irradiation. Water-soluble porphyrins have been used as the drug for photodynamic therapy (PDT) and photodynamic inactivation (PDI). Although usual water-solubilization of porphyrins has been achieved by an introduction of an ionic group such as ammonium, pyridinium, sulfonate, phosphonium, or carboxyl to porphyrin ring, we proposed the preparation of water-soluble P and Sb porphyrins by modification of axial ligands. Alkyl (type A), ethylenedioxy (type E), pyridinium (type P), and glucosyl groups (type G) were introduced to axial ligands of Sb and P porphyrins to achieve water-solubilization of Sb porphyrin and P porphyrins. Here, we review their water-soluble P and Sb porphyrins from the standpoints of preparation, bioaffinity, and photosensitized inactivation.