Photodynamic Therapy for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Table 1

Parameters of the studies included.

Author

Year

Mean age (year)

Female/male

Types of PS

Laser type

Radiant exposure (J/cm^2)

Power density (mW/cm^2)

Wavelength (nm)

Method of administration

Sample size

CR

OR

RR

Lesion locations

Sample size

CR

OR

Mean follow-up(month)

Exposure time(min)

Number of sessions

Adverse site

Ikeda H

2018

75.2 (55-94)

6/2

Talaporfin sodium

Diode laser

100

150

664

Intravenous

8

6

N/A

1

G/P^a; L/BM/T/FM^b

1; 7

0; 6

N/A; N/A

48

55-176

1

N/A

Toratani S

2016

70.8

22/12

Porfimer sodium

Dye laser

100-150

160

630

Intravenous

34

30

33

9

N/A

N/A

N/A

N/A

105

N/A

1

Sunburn and sequestrum formation of alveolar bone

Rigual N

2013

N/A

N/A

HPPH^d

Dye laser

Firstly:50-75/100-125.; Then:100-125/140

N/A

665

Intravenous

20

16

N/A

N/A

N/A

N/A

N/A

N/A

5-40

N/A

≥1

Expected pain and edema

Karakullukcu B

2013

60 (38-92)

22/33

mTHPC^c

N/A

N/A

N/A

630

N/A

55

49

N/A

N/A

N/A

N/A

N/A

N/A

24

N/A

1

N/A

Ikeda H

2013

73.7

N/A

Porfimer sodium

N/A

N/A

N/A

N/A

Intravenous

18

17

N/A

2

G/P; L/BM/T/FM

7; 11

6; 11

N/A; N/A

48

30-150

N/A

Swelling and edema

deVisscher S A

2013

61.1

N/A

mTHPC

Diode laser

N/A

100

630

Intravenous

156

127

N/A

N/A

N/A

N/A

N/A

N/A

33

N/A

1

N/A

Karakullukcu B

2011

60.5

N/A

mTHPC

N/A

N/A

100

652

Intravenous

126

86

114

N/A

G/P; L/BM/T/FM

26; 100

17; 69

23; 91

60

N/A

N/A

Scar formation

Jerjes W

2011

58

12/26

mTHPC

N/A

10-20

100

652

Intravenous

38

12

N/A

6

N/A

N/A

N/A

N/A

60

N/A

1

Pain and swelling

Merrill A. Biel

2010

N/A

N/A

Porfimer sodium

Dye laser

N/A

150

630

Intravenous

190

190

190

13

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

Vanessa Gayl

2010

N/A

N/A

Porfimer sodium

Pumped laser or a diode laser

50-100

100-200

630

Intravenous

26

22

26

4

N/A

N/A

N/A

N/A

N/A

N/A

≥1

N/A

KAI Johannes

2009

58.8 (48-62)

N/A

mTHPC

N/A

20

100

652

Intravenous

8

4

N/A

N/A

G/P; L/BM/T/FM

4; 4

2; 2

N/A; N/A

N/A

N/A

N/A

N/A

Rigual N R

2009

61.2 (36-85)

N/A

Porfimer sodium

Argon pumped dye laser or a diode laser

50-75

N/A

630

Intravenous

11

10

11

11

N/A

N/A

N/A

N/A

15

N/A

≥1

Pain edema itching, weight loss transient hoarseness

Hopper C

2004

64 (33-99)

N/A

mTHPC

Diode laser

20

100

652

Intravenous

114

97

114

N/A

G/P; L/BM/T/FM; Others

7; 103; 4

6; 87; 4

N/A; N/A; N/A

N/A

N/A

N/A

N/A

Copper M P

2003

N/A

N/A

mTHPC

Diode laser

20

100

652

Intravenous

26

22

N/A

4

G/P; L/BM/T/FM

5; 21

3; 19

N/A; N/A

37

N/A

N/A

N/A

Kubler A C

2001

64 (44-99)

6/19

mTHPC

N/A

20

100

652

Intravenous

25

24

N/A

2

G/P; L/BM/T/FM

N/A; 25

N/A; 24

N/A; N/A

14

N/A

N/A

Swelling and local pain

Kathleen F M

1997

66.5 (30-80)

N/A

Porfimer sodium

Dye laser

5-20

250

652

Intravenous

25

14

N/A

N/A

G/P

N/A

N/A

N/A

N/A

N/A

≥1

N/A

Yoshida T

1996

60.2 (51-67)

1/4

HPD^e

Argon or excimer dye laser

200

200-500

630

Intravenous

6

2

5

N/A

L/BM/T/FM

N/A

N/A

N/A

153

N/A

1

Inflammation swelling

Grant W E

1993

N/A

N/A

Porfimer sodium

Dye laser

50-100

150

630

Intravenous

14

13

N/A

N/A

G/P; L/BM/T/FM

3; 9

3; 8

N/A; N/A

10.63

N/A

N/A

N/A

G/P^a: gingiva and/or palate; L/BM/T/FM^b: lips and/or buccal mucosa and/or tongue and/or floor of the mouth. m-THPC^c: m-Tetra(hydroxyphenyl) chlorin; HPPH^d: chlorin-based compound, 3-(1’-hexyloxyethyl) pyropheophorbide; HPD^e: hematoporphyrin derivative. N/A: not applicable.