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International Journal of Pediatrics
Volume 2009, Article ID 274768, 3 pages
http://dx.doi.org/10.1155/2009/274768
Clinical Study

Fosfluconazole for Antifungal Prophylaxis in Very Low Birth Weight Infants

1Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan
2Division of Neonatology, Nagano Children’s Hospital, Azumino City, Nagano 399-8288, Japan

Received 26 January 2009; Accepted 8 April 2009

Academic Editor: Praveen Kumar

Copyright © 2009 Daijiro Takahashi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We conducted a retrospective case series study to evaluate the safety of fosfluconazole prophylaxis for preventing invasive fungal infection in VLBW infants with a central vascular access. Fosfluconazole was administered intravenously at a dose of 6 mg/kg everyday during which time a central venous catheter was placed. A total of 23 infants met the criteria for enrollment in our study. No cases of fungal infection were detected during the central venous catheter placement in the group. None of the infants had an elevated -D-glucan, and all of them were still alive at discharge. Regarding the liver and renal function, no statistically significant differences were observed before and at the end of fosfluconazole prophylaxis. The results of this study demonstrate that fosfluconazole prophylaxis in preventing invasive fungal infection was well tolerated by VLBW infants. This is a first report to describe antifungal prophylaxis using fosfluconazole for VLBW infants.