Case Report

Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review

Table 1

Overview of studies concerning progressive multifocal leukoencephalopathy in HIV-infected children.

AuthorYear reportedSexAge (years)CountryPresentationMRI/CTPrevious HIV- related eventHAART regimenCD4 T-cell % or count (cell/ L)Viral load (copies/mL)Outcome
BaselineNearest to episodeBaselineNearest to episode

Oberdorfer et al.2009M9ThailandRight hemiplegiaFrond-like hypodense lesion at the left frontal lobeNoneInitially nothing then AZT, 3TC, NVP0.210.21185 976185 976Dead
Liptai et al.2007M15 1/2HungaryDizzy, diplopia, clumsy right hand, unsteady gaitLarge, nonenhancing lesion of the right cerebellar heimsphere with a slight mass effectNone reportedInitially AZT, ddl then refused HAART3710.52900256 000Dead
Shah and Chudgar.2005F8 1/2IndiaRight-sided dystonia, inability to talk, eat, or sitAsymmetrical subcortical, right frontoparietal, left occipitoparietal and left vasal ganglia lesionsGeneralized tonic clonic seizures and loss of consciousnessInitially nothing then AZT, 3TC, EFV, NLF320Alive, still has dystonia
Robinson et al.2004M17USADysarthric speech, facial palsyMultiple confluent areas of high signal and fluid attenuated inversion recovery in the corona radiata bilaterallyPneumocystis jiroveci pneumoniaInitially AZT, 3TC then d4T, NVP, lopinavir/ ritonavir then included cidofovir3310–90 00029 100Stable, wide-based gait, dysarthria, right-sided tongue deviation
Nuttall et al.2004M12South AfricaAcute cerebellar dysfunction, hemiparesisNonenhancing low density lesion in the left cerebellar hemisphereGrowth failure, chronic lung diseased4T, 3TC, efavirenz1.085.4596 000UndetectableStable, mild cerebellar dysfunction
Inui et al.1999M12JabanLeft upper extremity weaknessWhite matter lesions of the right frontal, parietal and occipital lobesCandida stomatitisAZT then ritonavir and 3TC added9.57600Stable, left hemiparesis
Araujo et al.1997M10BrazilSubacute cerebellar dysfunction, dementiaFocal nonenhancing area of low attenuation in the cerebellumNone reported
Morriss et al.1997M7USADecreased activity, slurred speech, ataxiaConfluent, nonenhancing, low density lesion in the right cerebellar white matter, middle cerebellar peduncle and dorsolateral ponsCandida esophagitisddc0Death
Whiteman et al.1993M10USA
F12USAIncreased signal intensity in the basal ganglia and corona radiata bilaterally
Berger et al.1992F13USADysarthria, paresthesias of tongue and chinSinusitis and hyperintense signals in the basal gangliaOral candidiasisAZT4217Death
M10USAFacial palsyLeft frontal lobe lesionPneumocystis jiroveci pneumoniaAZT100Death
Vandersteenhoven et al.1992M7USADecreased activity, left hemiparesis, fallingBilateral confluent abnormal white matter hyperintensity in the region of the right subcortical/ periventricular regionNone reportedInitially nothing then AZT390Death