Pediatric Migraine

Table 5

Treatment of acute attacks of migraine.

Class	Drug	Comments
Analgesics	Ibuprofen, PO 7.5–10 mg/kg	First line drug; safe and effective in children
	Acetaminofen, PO 15 mg/kg	Comparable efficacy and safety profile with ibuprofen
	Nimuselide, PO 2.5 mg/kg
Triptans	Sumatriptan Nasal spray, 5 mg, 20 mg	Easy administration, faster initial relief, and more side effects as compared to placebo
	Subcutaneous, 0.06 mg/kg	Administration difficulty, chest and neck discomfort, and reported side effects
	Oral, 50 to 100 mg	Not effective
	Rizatriptan, PO, 5 mg	Studied in adolescent; adverse effects reported were fatigue, dizziness, somnolence, dry mouth, and nausea
	Zolmitriptan, PO 2.5–5 mg	Evaluated in 12–17 years
Other medication	Ketorolac IV 0.5 mg/kg; maximum 30 mg	IV prochlorperazine is superior to IV ketorolac in the acute treatment of migraine headaches in emergency department
	prochlorperazine IV (0.15 mg/kg; maximum 10 mg)