International Journal of Pediatrics / 2009 / Article / Tab 5

Review Article

Pediatric Migraine

Table 5

Treatment of acute attacks of migraine.

ClassDrugComments

AnalgesicsIbuprofen, PO 7.5–10 mg/kgFirst line drug; safe and effective in children
Acetaminofen, PO 15 mg/kgComparable efficacy and safety profile with ibuprofen
Nimuselide, PO 2.5 mg/kg

TriptansSumatriptan Nasal spray, 5 mg, 20 mgEasy administration, faster initial relief, and more side effects as compared to placebo
Subcutaneous, 0.06 mg/kgAdministration difficulty, chest and neck discomfort, and reported side effects
Oral, 50 to 100 mgNot effective
Rizatriptan, PO, 5 mgStudied in adolescent; adverse effects reported were fatigue, dizziness, somnolence, dry mouth, and nausea
Zolmitriptan, PO 2.5–5 mgEvaluated in 12–17 years

Other medicationKetorolac IV 0.5 mg/kg; maximum 30 mgIV prochlorperazine is superior to IV ketorolac in the acute treatment of migraine headaches in emergency department
prochlorperazine IV (0.15 mg/kg; maximum 10 mg)

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