Table of Contents Author Guidelines Submit a Manuscript
International Journal of Pediatrics
Volume 2009, Article ID 427682, 6 pages
http://dx.doi.org/10.1155/2009/427682
Clinical Study

Sepsis-Related Mortality of Very Low Birth Weight Brazilian Infants: The Role of Pseudomonas aeruginosa

1Post-Graduate Department, Fernandes Figueira Institute, Rui Barbosa Avenue, 716, Flamengo, Rio de Janeiro 22250-020, Brazil
2Neonatology Department, Servidores do Estado Hospital, Sacadura Cabral Street 178, Saúde, Rio de Janeiro 20221-903, Brazil
3Pediatrics Institute IPPMG Pediatrics Department, Federal University of Rio de Janeiro, Bruno Lobo Avenue, 50, Ilha do Fundão, Rio de Janeiro 21914 912, Brazil
4Estacio De Sa University, Riachvelo Street 27-Centro, Riode Janeiro, CEP 20230-010, Brazil
5Epidemiology Department, Servidores do Estado Hospital, Sacadura Cabral Street 178, Saúde, Rio de Janeiro 20221-903, Brazil
6Hospital Infection Control Department, Servidores do Estado Hospital, Sacadura Cabral Street 178, Saúde, Rio de Janeiro 20221-903, Brazil
7Medical Residence, Fernandes Figueira Institute, Rui Barbosa Avenue, 716, Flamengo, Rio de Janeiro 22250-020, Brazil

Received 9 May 2009; Revised 29 September 2009; Accepted 23 December 2009

Academic Editor: Sunit C. Singhi

Copyright © 2009 Sylvia Maria Porto Pereira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study is to identify risk factors for sepsis-related mortality in low birth weight (<1500 g) infants. We performed retrospective cohort study to investigate risk factors for sepsis-related mortality in all neonates birth weight <1500 g admitted to Level III neonatal intensive care unit, Brazil, April 2001/September 2004. Of the 203 cases, 71 (35%) had sepsis. Of those, gram-positive was identified in 52/87 blood cultures (59.8%), the most common Coagulase-negative Staphylococcus (31/87; 35.5%). Gram-negative was present in 29 of the 87 positive blood cultures (33.3%), with Pseudomonas aeruginosa (8/87; 9.1%), the most frequent agent. Overall 21 of 71 infants with sepsis (29.6%) died. Risk factors for sepsis-related mortality were gestational age ≤28 weeks, birth weight ≤1000 g (9.6 times more often than birth weight >1000 g), five-minute Apgar ≤7, gram-negative sepsis, mechanical ventilation (6.7 times higher than no use), and intravascular catheter. Sepsis-related mortality was due, mainly, to Pseudomonas aeruginosa; birth weight ≤1000 g and mechanical ventilation were strong sepsis-related mortality predictors.