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International Journal of Pediatrics
Volume 2010, Article ID 254829, 6 pages
http://dx.doi.org/10.1155/2010/254829
Clinical Study

Exercise Stress Testing in Children with Metabolic or Neuromuscular Disorders

1Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, NL 3508 AB Utrecht, The Netherlands
2Faculty of Medicine, Vrije University Medical Center, NL 1007 MB Amsterdam, The Netherlands
3Department of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, NL 3508 AB Utrecht, The Netherlands
4Department of Metabolic and Endocrine Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, NL 3508 AB Utrecht, The Netherlands

Received 7 January 2010; Revised 10 May 2010; Accepted 15 June 2010

Academic Editor: Miles Weinberger

Copyright © 2010 Tim Takken et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The role of exercise as a diagnostic or therapeutic tool in patients with a metabolic disease (MD) or neuromuscular disorder (NMD) is relatively underresearched. In this paper we describe the metabolic profiles during exercise in 13 children (9 boys, 4 girls, age 5–15 yrs) with a diagnosed MD or NMD. Graded cardiopulmonary exercise tests and/or a 90-min prolonged submaximal exercise test were performed. During exercise, respiratory gas-exchange and heart rate were monitored; blood and urine samples were collected for biochemical analysis at set time points. Several characteristics in our patient group were observed, which reflected the differences in pathophysiology of the various disorders. Metabolic profiles during exercises CPET and PXT seem helpful in the evaluation of patients with a MD or NMD.