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International Journal of Pediatrics
Volume 2010 (2010), Article ID 379792, 8 pages
http://dx.doi.org/10.1155/2010/379792
Review Article

The Fetal Heart in Twin-to-Twin Transfusion Syndrome

University Hospitals Leuven, Division of Woman and Child, Department of Obstetrics and Gynecology, Fetal Diagnosis and Therapy Unit, Herestraat 49, 3000 Leuven, Belgium

Received 9 March 2010; Accepted 12 July 2010

Academic Editor: Shinjiro Hirose

Copyright © 2010 Tim Van Mieghem et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Lewi, J. Jani, and J. Jani, “The outcome of monochorionic diamniotic twin gestations in the era of invasive fetal therapy: a prospective cohort study,” American Journal of Obstetrics and Gynecology, vol. 199, no. 5, pp. 514.e1–514.e8, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. N. J. Sebire, A. Souka, H. Skentou, L. Geerts, and K. H. Nicolaides, “Early prediction of severe twin-to-twin transfusion syndrome,” Human Reproduction, vol. 15, no. 9, pp. 2008–2010, 2000. View at Google Scholar · View at Scopus
  3. L. Lewi, M. Cannie, and M. Cannie, “Placental sharing, birthweight discordance, and vascular anastomoses in monochorionic diamniotic twin placentas,” American Journal of Obstetrics and Gynecology, vol. 197, no. 6, pp. 587.e1–587.e8, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. K. E. A. Hack, P. G. J. Nikkels, C. Koopman-Esseboom, J. B. Derks, S. G. Elias, M. J. C. van Gemert, and G. H. A. Visser, “Placental characteristics of monochorionic diamniotic twin pregnancies in relation to perinatal outcome,” Placenta, vol. 29, no. 11, pp. 976–981, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. M. L. Denbow, P. Cox, M. Taylor, D. M. Hammal, and N. M. Fisk, “Placental angioarchitecture in monochorionic twin pregnancies: relationship to fetal growth, fetofetal transfusion syndrome, and pregnancy outcome,” American Journal of Obstetrics and Gynecology, vol. 182, no. 2, pp. 417–426, 2000. View at Google Scholar · View at Scopus
  6. M. L. Denbow, P. Cox, D. Talbert, and N. M. Fisk, “Colour Doppler energy insonation of placental vasculature in monochorionic twins: absent arterio-arterial anastomoses in association with twin-to-twin transfusion syndrome,” British Journal of Obstetrics and Gynaecology, vol. 105, no. 7, pp. 760–765, 1998. View at Google Scholar · View at Scopus
  7. N. M. Fisk, G. J. Duncombe, and M. H. F. Sullivan, “The basic and clinical science of twin-twin transfusion syndrome,” Placenta, vol. 30, no. 5, pp. 379–390, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. R. A. Quintero, W. J. Morales, M. H. Allen, P. W. Bornick, P. K. Johnson, and M. Kruger, “Staging of twin-twin transfusion syndrome,” Journal of Perinatology, vol. 19, no. 8, pp. 550–555, 1999. View at Google Scholar · View at Scopus
  9. V. Berghella and M. Kaufmann, “Natural history of twin-twin transfusion syndrome,” Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 46, no. 5, pp. 480–484, 2001. View at Google Scholar · View at Scopus
  10. C. Barrea, F. Alkazaleh, and F. Alkazaleh, “Prenatal cardiovascular manifestations in the twin-to-twin transfusion syndrome recipients and the impact of therapeutic amnioreduction,” American Journal of Obstetrics and Gynecology, vol. 192, no. 3, pp. 892–902, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. M.-V. Senat, J. Deprest, M. Boulvain, A. Paupe, N. Winer, and Y. Ville, “Endoscopic laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome,” The New England Journal of Medicine, vol. 351, no. 2, pp. 136–144, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. R. Lenclen, G. Ciarlo, A. Paupe, L. Bussieres, and Y. Ville, “Neurodevelopmental outcome at 2 years in children born preterm treated by amnioreduction or fetoscopic laser surgery for twin-to-twin transfusion syndrome: comparison with dichorionic twins,” American Journal of Obstetrics and Gynecology, vol. 201, no. 3, pp. 291.e1–291.e5, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. N. Maiz, I. Staboulidou, A. M. Leal, R. Minekawa, and K. H. Nicolaides, “Ductus venosus Doppler at 11 to 13 weeks of gestation in the prediction of outcome in twin pregnancies,” Obstetrics and Gynecology, vol. 113, no. 4, pp. 860–865, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. K. O. Kagan, A. Gazzoni, G. Sepulveda-Gonzalez, A. Sotiriadis, and K. H. Nicolaides, “Discordance in nuchal translucency thickness in the prediction of severe twin-to-twin transfusion syndrome,” Ultrasound in Obstetrics and Gynecology, vol. 29, no. 5, pp. 527–532, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. A. Matias, N. Montenegro, T. Loureiro, M. Cunha, S. Duarte, D. Freitas, and M. Severo, “Screening for twin-twin transfusion syndrome at 11–14 weeks of pregnancy: the key role of ductus venosus blood flow assessment,” Ultrasound in Obstetrics and Gynecology, vol. 35, no. 2, pp. 142–148, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. L. Lewi, P. Lewi, and P. Lewi, “The role of ultrasound examination in the first trimester and at 16 weeks' gestation to predict fetal complications in monochorionic diamniotic twin pregnancies,” American Journal of Obstetrics and Gynecology, vol. 199, no. 5, pp. 493.e1–493.e7, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. S. Molina, R. Papanna, K. J. Moise Jr., and A. Johnson, “Management of stage I twin-to-twin transfusion syndrome: an international survey,” Ultrasound in Obstetrics and Gynecology, vol. 36, no. 1, pp. 42–47, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. T. Van Mieghem, P. DeKoninck, P. Steenhaut, and J. Deprest, “Methods for prenatal assessment of fetal cardiac function,” Prenatal Diagnosis, vol. 29, no. 13, pp. 1193–1203, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. M. Habli, E. Michelfelder, J. Livingston, J. Harmon, F. Y. Lim, W. Polzin, and T. Crombleholme, “Acute effects of selective fetoscopic laser photocoagulation on recipient cardiac function in twin-twin transfusion syndrome,” American Journal of Obstetrics and Gynecology, vol. 199, no. 4, pp. 412.e1–412.e6, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. M. Sueters, J. M. Middeldorp, and J. M. Middeldorp, “The effect of fetoscopic laser therapy on fetal cardiac size in twin-twin transfusion syndrome,” Ultrasound in Obstetrics and Gynecology, vol. 31, no. 2, pp. 158–163, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. J. Rychik, Z. Tian, and Z. Tian, “The twin-twin transfusion syndrome: spectrum of cardiovascular abnormality and development of a cardiovascular score to assess severity of disease,” American Journal of Obstetrics and Gynecology, vol. 197, no. 4, pp. 392.e1–392.e8, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. A. A. Karatza, J. L. Wolfenden, M. J. O. Taylor, L. Wee, N. M. Fisk, and H. M. Gardiner, “Influence of twin-twin transfusion syndrome on fetal cardiovascular structure and function: prospective case-control study of 136 monochorionic twin pregnancies,” Heart, vol. 88, no. 3, pp. 271–277, 2002. View at Google Scholar · View at Scopus
  23. J. J. Stirnemann, M. Mougeot, F. Proulx, B. Nasr, M. Essaoui, J. C. Fouron, and Y. Ville, “Profiling fetal cardiac function in twin-twin transfusion syndrome,” Ultrasound in Obstetrics and Gynecology, vol. 35, no. 1, pp. 19–27, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. E. Michelfelder, W. Gottliebson, and W. Gottliebson, “Early manifestations and spectrum of recipient twin cardiomyopathy in twin-twin transfusion syndrome: relation to Quintero stage,” Ultrasound in Obstetrics and Gynecology, vol. 30, no. 7, pp. 965–971, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. T. Van Mieghem, S. Giusca, and S. Giusca, “Prospective assessment of fetal cardiac function with speckle tracking in healthy fetuses and recipient fetuses of twin-to-twin transfusion syndrome,” Journal of the American Society of Echocardiography, vol. 23, no. 3, pp. 301–308, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. M. Sueters, J. M. Middeldorp, and J. M. Middeldorp, “Fetal cardiac output in monochorionic twins,” Ultrasound in Obstetrics and Gynecology, vol. 32, no. 6, pp. 807–812, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. A. Szwast, Z. Tian, and Z. Tian, “Impact of altered loading conditions on ventricular performance in fetuses with congenital cystic adenomatoid malformation and twin-twin transfusion syndrome,” Ultrasound in Obstetrics and Gynecology, vol. 30, no. 1, pp. 40–46, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. T. Van Mieghem, E. Doné, and E. Doné, “Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome,” American Journal of Obstetrics and Gynecology, vol. 202, pp. 48.e1–48.e7, 2010. View at Publisher · View at Google Scholar · View at PubMed
  29. B. Bensouda, J.-C. Fouron, M.-J. Raboisson, J. Lamoureux, C. Lachance, and L. Leduc, “Relevance of measuring diastolic time intervals in the ductus venosus during the early stages of twin-twin transfusion syndrome,” Ultrasound in Obstetrics and Gynecology, vol. 30, no. 7, pp. 983–987, 2007. View at Publisher · View at Google Scholar · View at PubMed
  30. M. J. Raboisson, J. C. Fouron, J. Lamoureux, L. Leduc, A. Grignon, F. Proulx, and S. Gamache, “Early intertwin differences in myocardial performance during the twin-to-twin transfusion syndrome,” Circulation, vol. 110, no. 19, pp. 3043–3048, 2004. View at Publisher · View at Google Scholar · View at PubMed
  31. T. Tsutsumi, M. Ishii, G. Eto, M. Hota, and H. Kato, “Serial evaluation for myocardial performance in fetuses and neonates using a new Doppler index,” Pediatrics International, vol. 41, no. 6, pp. 722–727, 1999. View at Publisher · View at Google Scholar
  32. C. Tei, L. H. Ling, and L. H. Ling, “New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function—a study in normals and dilated cardiomyopathy,” Journal of Cardiology, vol. 26, no. 6, pp. 357–366, 1995. View at Google Scholar
  33. T. Van Mieghem, L. Gucciardo, and L. Gucciardo, “Validation of the fetal myocardial performance index in the second and third trimesters of gestation,” Ultrasound in Obstetrics and Gynecology, vol. 33, no. 1, pp. 58–63, 2009. View at Publisher · View at Google Scholar · View at PubMed
  34. L. Zikulnig, K. Hecher, T. Bregenzer, E. Bäz, and B. J. Hackelöer, “Prognostic factors in severe twin-twin transfusion syndrome treated by endoscopic laser surgery,” Ultrasound in Obstetrics and Gynecology, vol. 14, no. 6, pp. 380–387, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. D. Mahieu-Caputo, L. J. Salomon, and L. J. Salomon, “Fetal hypertension: an insight into the pathogenesis of the twin-twin transfusion syndrome,” Prenatal Diagnosis, vol. 23, no. 8, pp. 640–645, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. T. Van Mieghem, E. Eixarch, L. Gucciardo et al., “Outcome prediction in monochorionic diamniotic twin pregnancies with moderately discordant amniotic fluid,” American Journal of Obstetrics and Gynecology, vol. 201, article S38, 2009. View at Google Scholar
  37. I. H. Linskens, Y. M. de Mooij, J. W. Twisk, W. J. Kist, D. Oepkes, and J. M. van Vugt, “Discordance in nuchal translucency measurements in monochorionic diamniotic twins as predictor of twin-to-twin transfusion syndrome,” Twin Research and Human Genetics, vol. 12, no. 6, pp. 605–610, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. N. Zosmer, R. Bajoria, E. Weiner, M. Rigby, J. Vaughan, and N. M. Fisk, “Clinical and echographic features of in utero cardiac dysfunction in the recipient twin in twin-twin transfusion syndrome,” British Heart Journal, vol. 72, no. 1, pp. 74–79, 1994. View at Google Scholar · View at Scopus
  39. J. D. Pruetz, R. H. Chmait, and M. S. Sklansky, “Complete right heart flow reversal: pathognomonic recipient twin circular shunt in twin-twin transfusion syndrome,” Journal of Ultrasound in Medicine, vol. 28, no. 8, pp. 1101–1106, 2009. View at Google Scholar · View at Scopus
  40. T. Van Mieghem, P. Klaritsch, and P. Klaritsch, “Assessment of fetal cardiac function before and after therapy for twin-to-twin transfusion syndrome,” American Journal of Obstetrics and Gynecology, vol. 200, no. 4, pp. 400.e1–400.e7, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. J. van den Boom, M. Battin, and T. Hornung, “Twin-twin transfusion syndrome, coarctation of the aorta and hypoplastic aortic arch: a case series report,” Journal of Paediatrics and Child Health, vol. 46, no. 3, pp. 76–79, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. D. Mahieu-Caputo, A. Meulemans, and A. Meulemans, “Paradoxic activation of the renin-angiotensin system in twin-twin transfusion syndrome: an explanation for cardiovascular disturbances in the recipient,” Pediatric Research, vol. 58, no. 4, pp. 685–688, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  43. R. Bajoria, S. Ward, and R. Chatterjee, “Natriuretic peptides in the pathogenesis of cardiac dysfunction in the recipient fetus of twin-twin transfusion syndrome,” American Journal of Obstetrics and Gynecology, vol. 186, no. 1, pp. 121–127, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. R. Bajoria, S. Ward, and R. Chatterjee, “Brain natriuretic peptide and endothelin-1 in the pathogenesis of polyhydramnios-oligohydramnios in monochorionic twins,” American Journal of Obstetrics and Gynecology, vol. 189, no. 1, pp. 189–194, 2003. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Delabaere, G. Marceau, S. Kemeny, V. Sapin, S. Ughetto, K. Coste, and D. Gallot, “Intra-amniotic N-terminal pro-brain natriuretic peptide in severe twin-to-twin transfusion syndrome treated by fetoscopic laser coagulation,” Ultrasound in Obstetrics and Gynecology, vol. 35, no. 5, pp. 620–621, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  46. K. E. Porter and N. A. Turner, “Cardiac fibroblasts: at the heart of myocardial remodeling,” Pharmacology and Therapeutics, vol. 123, no. 2, pp. 255–278, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  47. Y. Ville, “Twin-to-twin transfusion syndrome: time to forget the Quintero staging system?” Ultrasound in Obstetrics and Gynecology, vol. 30, no. 7, pp. 924–927, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  48. A. D. Shah, W. L. Border, T. M. Crombleholme, and E. C. Michelfelder, “Initial fetal cardiovascular profile score predicts recipient twin outcome in twin-twin transfusion syndrome,” Journal of the American Society of Echocardiography, vol. 21, no. 10, pp. 1105–1108, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  49. A. Huber, W. Diehl, T. Bregenzer, B.-J. Hackelöer, and K. Hecher, “Stage-related outcome in twin-twin transfusion syndrome treated by fetoscopic laser coagulation,” Obstetrics and Gynecology, vol. 108, no. 2, pp. 333–337, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  50. L. L. Simpson, G. R. Marx, E. A. Elkadry, and M. E. D'Alton, “Cardiac dysfunction in twin-twin transfusion syndrome: a prospective, longitudinal study,” Obstetrics and Gynecology, vol. 92, no. 4, pp. 557–562, 1998. View at Publisher · View at Google Scholar · View at Scopus
  51. C. Barrea, L. K. Hornberger, and L. K. Hornberger, “Impact of selective laser ablation of placental anastomoses on the cardiovascular pathology of the recipient twin in severe twin-twin transfusion syndrome,” American Journal of Obstetrics and Gynecology, vol. 195, no. 5, pp. 1388–1395, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  52. V. Fesslova, L. Villa, S. Nava, F. Mosca, and U. Nicolini, “Fetal and neonatal echocardiographic findings in twin-twin transfusion syndrome,” American Journal of Obstetrics and Gynecology, vol. 179, no. 4, pp. 1056–1062, 1998. View at Publisher · View at Google Scholar · View at Scopus
  53. P. H. Gray, C. Ward, and F.-Y. Chan, “Cardiac outcomes of hydrops as a result of twin-twin transfusion syndrome treated with laser surgery,” Journal of Paediatrics and Child Health, vol. 45, no. 1-2, pp. 48–52, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  54. E. Gratacós, D. Van Schoubroeck, E. Carreras, R. Devlieger, E. Roma, L. Cabero, and J. Deprest, “Transient hydropic signs in the donor fetus after fetoscopic laser coagulation in severe twin-twin transfusion syndrome: incidence and clinical relevance,” Ultrasound in Obstetrics and Gynecology, vol. 19, no. 5, pp. 449–453, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  55. E. Eixarch, K. Ty-Torredes, T. Van Mieghem et al., “Contribution of Doppler and cardiac function evaluation to the prediction of the individualized risk of early fetal demise after laser therapy in twin-twin transfusion syndrome,” Ultrasound in Obstetrics and Gynecology, vol. 34, p. 42, 2009. View at Google Scholar
  56. C. P. Halvorsen, S. L. Bilock, C. Pilo, S.-E. Sonesson, and M. Norman, “Childhood cardiac function after twin-to-twin transfusion syndrome—a 10-year follow up,” Acta Paediatrica, International Journal of Paediatrics, vol. 98, no. 9, pp. 1468–1474, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  57. Y. F. Cheung, M. J. O. Taylor, N. M. Fisk, A. N. Redington, and H. M. Gardiner, “Fetal origins of reduced arterial distensibility in the donor twin in twin-twin transfusion syndrome,” The Lancet, vol. 355, no. 9210, pp. 1157–1158, 2000. View at Google Scholar · View at Scopus
  58. H. M. Gardiner, M. J. O. Taylor, and M. J. O. Taylor, “Twin-twin transfusion syndrome: the influence of intrauterine laser photocoagulation on arterial distensibility in childhood,” Circulation, vol. 107, no. 14, pp. 1906–1911, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  59. U. Herberg, W. Gross, P. Bartmann, C. S. Banek, K. Hecher, and J. Breuer, “Long term cardiac follow up of severe twin to twin transfusion syndrome after intrauterine laser coagulation,” Heart, vol. 92, no. 1, pp. 95–100, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus