Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism

Figure 3

Multivariate association of main and interactive effects of zinc supplementation and diarrheal isolates using stepwise logistic regression models for two diarrhea-related outcomes—risk of continued diarrhea for 3 or more days (left column) and high stool volume (right column). In this grid, yellow background indicates the main effects, black circle indicates the included covariate, the blue background indicates interactive effects, and black circles in the blue part of the grid indicate the interactions among the circled covariates. Z: zinc supplementation; E: Escherichia coli; K: Klebsiella; and R: rotavirus. Diamonds and error bars indicate the point and 95% confidence interval estimates for the log odds ratio (Log OR). Results are from full model (on the left) and final model (on the right) from the stepwise logistic regression analyses. The full model included all the 14 covariates indicated in the grid while the stepwise regression analyses used a backward elimination strategy with a probability retention criterion of 0.2. Numbers at the right-hand side in the final model plots are significance values for the covariates that were retained in the final model.