Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism
Table 1
Influence of zinc supplementation on risk of diarrhea 3 days in different subgroups based on the isolated organisms
Subgroup
N
Zn verses Pl
verses Pl
Any zin verses Pl
95% CI
P
OR
95% CI
P
OR
95% CI
P
All children
Overall
798
1.16
0.81–1.67
.421
1.05
0.73–1.50
.808
1.10
0.80–1.51
.547
E. coli infection
449
1.59
0.96–2.61
.069
1.42
0.97–2.33
.164
1.50
0.97–2.32
.068
E. coli single infection
273
1.32
0.68–2.57
.413
1.16
0.59–2.26
.667
1.24
0.69–2.22
.477
Klebsiella infection
275
0.73
0.39–1.36
.322
0.58
0.31–1.09
.092
0.65
0.38–1.12
.121
Klebsiella single infection
170
0.46
0.20–1.05
.065
0.43
0.18–0.98
.045
0.44
0.22–0.90
.025
Rotavirus infection
169
2.30
0.98–5.39
.054
3.00
1.31–6.87
.009
2.65
1.28–5.48
.009
E. coli + rotavirus mixed infection
100
2.43
0.71–8.33
.159
4.54
1.33–15.5
.016
3.39
1.13–10.1
.029
Klebsiella + rotavirus mixed infection
53
2.29
0.36–14.6
.381
1.50
0.33–6.91
.600
1.72
0.42–7.05
.444
Children with RBCs in stoold
Overall
334
1.33
0.74–2.40
.341
1.04
0.58–1.88
.879
1.18
0.71–1.97
.537
E. coli infection
193
2.20
0.99–4.91
.054
1.81
0.83–3.91
.135
1.98
0.98–3.98
.056
E. coli single infection
121
2.21
0.69–7.10
.183
1.44
0.47–4.51
.522
1.76
0.62–4.91
.282
Klebsiella infection
109
0.51
0.15–1.65
.260
0.26
0.08–0.91
.035
0.37
0.13–1.08
.069
Klebsiella single infection
64
0.37
0.07–2.12
.262
0.23
0.04–1.23
.085
0.28
0.06–1.27
.099
ll the results are from multivariate logistic regression analyses which adjusted for effects of age, gender, presence of stunting (weight-for-age z-score −2), presence of wasting (length-for-age z-score −2), wealth index score, hand washing score, baseline plasma zinc level, baseline plasma copper level, and baseline hemoglobin level. receiving zinc alone or zinc and copper compared to those receiving placebo. : odds ratio; CI: confidence interval; : number of subjects with complete covariate information; Zn: zinc, Zn + Cu: zinc and copper; Pl: placebo. were only 28 children with Rotavirus isolates who had RBCs in stool. Due to this small number, analyses separately for the Rotavirus group have not been carried out.
