Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism

Table 2

Influence of zinc supplementation on the outcome of high stool volume in different subgroups based on the isolated organisms.^𝑎

Subgroup	N	Zn verses Pl			Zn+Cu verses Pl			Any zinc^b verses Pl
		OR^c	95% CI	P	OR	95% CI	P	OR	95% CI	P
Overall	798	0.88	0.62–1.26	.496	0.88	0.62–1.25	.472	0.88	0.65–1.20	.418
E. coli infection	449	1.17	0.72–1.89	.519	1.41	0.87–2.26	.159	1.29	0.85–1.95	.236
E. coli single infection	273	0.97	0.52–1.81	.922	1.20	0.65–2.22	.560	1.08	0.63–1.86	.776
Klebsiella infection	275	0.67	0.36–1.24	.204	0.55	0.30–1.03	.062	0.61	0.36–1.04	.071
Klebsiella single infection	170	0.70	0.31–1.58	.395	0.48	0.21–1.08	.077	0.58	0.29–1.18	.131
Rotavirus infection	169	1.44	0.62–3.39	.398	2.31	0.99–5.39	.052	1.85	0.89–3.84	.097
E. coli + rotavirus mixed infection	100	1.19	0.35–4.00	.781	2.44	0.72–8.27	.151	1.74	0.59–5.09	.313
Klebsiella + rotavirus mixed infection	53	0.92	0.14–6.08	.930	2.09	0.37–11.9	.408	1.51	0.32–7.07	.601

^aAll the results are from multivariate logistic regression analyses which adjusted for effects of age, gender, presence of stunting (weight-for-age z-score <−2), presence of wasting (length-for-age z-score <−2), wealth index score, hand washing score, baseline plasma zinc level, baseline plasma copper level, and baseline hemoglobin level.
^bChildren receiving zinc alone or zinc and copper compared to those receiving placebo.
^cOR: odds ratio; CI: confidence interval; 𝑁: number of subjects with complete covariate information; Zn: zinc, Zn + Cu: zinc and copper; Pl: placebo.