Serum Levels of Natriuretic Peptides in Children before and after Treatment for an Atrial Septal Defect, a Patent Ductus Arteriosus, and a Coarctation of the Aorta—A Prospective Study
Table 3
Two- and three-dimensional echocardiographic findings in control subjects and in groups of children with ASD, PDA, and CoA, measured at baseline and at 6 and 12 months after repair. Values are given as median (range).
Diagnosis
Controls
ASD
PDA
CoA
baseline
6 months
12 months
baseline
6 months
baseline
6 months
12 months
f-u
f-u
f-u
f-u
f-u
76
21
21
25
25
15
15
13
IVSED
0.00
0.25
0.00
0.50
0.50
0.25
1.25
0.50
1.50
(SD)
(2.00–2.75)
(1.00–3.75)
(2.00–1.25)
(1.50–2.50)
(1.75–4.50)
(1.75–4.25)
(0.75–5.00)
(1.25–2.50)
(0.00–2.75)
LVPWED
0.50
0.25
0.25
0.00
0.50
0.25
0.25
0.00
0.75
(SD)
(2.25–2.00)
(1.50–2.00)
(2.25–1.00)
(1.25–1.25)
(2.00–2.75)
(1.25–2.25)
(2.50–1.75)
(1.50–1.50)
(0.75–1.75)
RVEDD
0.25
4.75
1.25
2.25
0.125
0.625
0.375
0.75
0.50
(SD)
(1.75–2.50)
(2.25–9.75)
(1.50–5.50)
(0.25–3.50)
(1.75–2.75)
(1.75–3.50)
(2.25–1.75)
(2.00–2.00)
(2.25–1.75)
LVEDD
0.25
1.50
0.00
0.50
0.75
0.00
0.75
1.00
1.00
(SD)
(−1.75– 2.00)
(3.75–0.00)
(3.00–1.25)
(1.75–1.25)
(1.25–3.75)
(2.00–1.75)
(1.25–4.25)
(1.00–3.25)
(0.50–2.00)
LVEDV
62.1
47.2
63.0
60.4
78.4
64.2
75.0
65.8
72.5
(mL/m²)
(36.9–87.7)
(27.6–67.1)
(35.5–83.1)
(43.5–92.9)
(44.7–117.1)
(37.6–89.5)
(47.9–115.6)
(49.8–98.5)
(52.5–82.4)
LVESV
19.3
13.2
18.5
19.4
24.5
19.5
19.7
18.4
18.5
(mL/m²)
(7.7–30.6)
(7.4–33.2)
(8.0–28.2)
(12.5–31.8)
(12.3–45.0)
(11.9–33.3)
(12.8–68.1)
(8.9–37.4)
(9.2–32.8)
LVED3D
56.2
49.2
63.5
65.1
57.5
57.7
64.7
61.4
71.4
(mL/m²)
(32.0–89.5)
(31.0–65.3)
(36.5–93.8)
(40.0–107.6)
(43.6–99.4)
(41.0–84.2)
(35.6–145.3)
(30.7–131.1)
(35.7–121.2)
LVES3D
28.5
24.1
31.0
33.8
29.8
27.6
38.1
28.8
30.2
(mL/m²)
(14.1–52.8)
(16.2–38.8)
(17.5–45.7)
(18.1–48.9)
(19.4–54.1)
(18.1–37.6)
(16.8–93.5)
(9.3–80.1)
(14.9–56.5)
ASD: atrial septal defect, CoA: coarctation of the aorta; IVSED (SD): z-score (SD) of the end-diastolic thickness of interventricular septum; LVEDD (SD): z-score (SD) of the end-diastolic diameter of left ventricle; LVESD (SD): z-score (SD) of the end-systolic diameter of left ventricle; LVEDV: end-diastolic volume of left ventricle adjusted for body surface area; LVESV: end-systolic volume of left ventricle adjusted for body surface area; LVED3D: end-diastolic volume of left ventricle adjusted for body surface area measured by 3D echocardiography; LVES3D: end-systolic volume of left ventricle adjusted for body surface area measured by 3D echocardiography, LVPWED (SD): z-score (SD) of the end-diastolic thickness of left ventricular posterior wall; PDA: patent ductus arteriosus; RVEDD (SD): z-score (SD) of the end-diastolic diameter of right ventricle; SD: standard deviation of published normal values; § as compared with control group; † as compared with baseline.
