Induced Sputum Substance P in Children with Difficult-to-Treat Bronchial Asthma and Gastroesophageal Reflux: Effect of Esomeprazole Therapy

Table 2

Demographic data, C-ACT, FEV₁, PEF variability, and induced sputum SP in patient group with difficult-to-treat asthma with and without GERD.

	Difficult-to-treat asthma with GERD 𝑁=29	Difficult-to-treat asthma without GERD 𝑁=30	t	P
Age	7.97±1.56	7.96±1.8	0.03	>0.05
Sex M : F	15 : 14	16 : 14
BMI	20.5±2.5	21.0±2.05	0.88	>0.05
Age at diagnosis	4.7±1.6	4.9±1.4	0.4	>0.05
C-ACT	12.7±3.9	12.8±3.2	0.12	>0.05
FEV1 (% of predicted)	57.1±7.9	60.1±4.7	1.8	>0.05
PEF variability (%)	40.7±5.6	39.4±3.6	1.2	>0.05
SP (pg/mL)	1503±84	1004±258	9.2	<0.001*

BMI: body mass index; C-ACT: childhood asthma control test; EFV₁: forced expiratory volume in 1 second; PEF variability: peak expiratory flow variability; sputum SP: sputum levels of substance P.
*Significant.