Postnatal Corticosteroids for Prevention and Treatment of Chronic Lung Disease in the Preterm Newborn

Table 3

RCTs of early hydrocortisone to prevent BPD.

Study, no. of centers	n	Population: mechanically ventilated infants	Timing	Hydrocortisone dosing regimen	Rate of survival without BPD HC versus placebo, %
Watterberg et al. [49], 2 centers	40	BW: 500–999 g	<48 h postnatal age	0.5 mg/kg every 12 h for 9 days; 0.25 mg/kg every 12 h for 3 days	60 versus 35 (𝑃=.04)
Watterberg et al. [50], 9 centers	360	BW: 500–999 g	<48 h postnatal age	0.5 mg/kg every 12 h for 12 days; 0.25 mg/kg every 12 h for 3 days	35 versus 34 (OR: 1.20 (95% CI: 0.72–1.99))
Peltoniemi et al. [51], 3 centers	51	BW: 501–1250 g	<36 h postnatal age	2.0 mg/kg/day tapered to0.75 mg/kg/day over 10 days	64 versus 46 (OR: 1.48 (95% CI: 0.49–4.48))
Bonsante et al. [52], 2 centers	50	BW: 500–1249 g	<48 h postnatal age	0.5 mg/kg every 12 h for 9 days; 0.25 mg/kg every 12 h for 3 days	64 versus 32 (𝑃<.05)