International Journal of Pediatrics / 2012 / Article / Tab 2

Clinical Study

A Population-Based Study of Meconium Aspiration Syndrome in Neonates Born between 37 and 43 Weeks of Gestation

Table 2

Case-control comparison in a population of neonates with GA ≥37 weeks and born through MSAF. Cases are severe MAS (i.e., treated by mechanical ventilation and/or continuous positive airway pressure). Paired neonates without respiratory symptoms are controls.

Cases Controls value

Characteristics of the mother
Age (years)29.7 ± 5.828.9 ± 5.20.23
Nulliparity (%)59.558.10.80
Past history of (%)7.957.870.97

Characteristics of pregnancy
 Multiple pregnancy (%)01.50.24
 Insufficient followup care (%)8.990.75<0.0001
 Smoking (%)21.618.50.52
 Hypertension or preeclampsia (%)2.284.910.28
 Oligohydramnios (%)4.53.40.62
 Antenatal diagnosis of (%)1.122.640.40
 Gestational diabetes (%)2.286.00.16
 Clinical chorioamnionitis (%)001.0
vaginal carriage (%)12.99.40.35
 Placenta praevia (%)001.0
 Placental abruption (%)001.0

Characteristics of delivery
 Cord abnormalities23.626.70.53
(>12 hr)4.69.70.13
 Antenatal steroid therapy2.200.25

Birth place:
 Level I (%)16.811.2
 Level II (%)49.577.
 Level III (%)33.711.2<0.0001
 Day time delivery (%)56.242.60.02
 Induction of labor (%)27.028.10.83

Meconium in amniotic fluid <0.0001
 Thin (%)33.776.4
 Moderate (%)55.122.8
 Thick (%)11.20.78
 Amnioinfusion (%)7.91.90.0067

Fetal Heart Rate (FHR):
 Tachycardia (%)17.24.50.0001
 Bradycardia (%)49.432.90.0057

Presentation:
 Cephalic (%)95.597.4
 Breech (%)3.41.90.37
 Other (%)1.10.7

Anesthesia
  (i) Spinal (%)14.69.4
  (ii) Epidural (%)69.767.0
  (iii) General (%)2.23.00.29
  (iv) No anesthesia (%)13.520.6

Mode of Delivery
 CS (%)37.220.2
 Vaginal with manoeuvres (%)17.917.9
 Vaginal without manoeuvres (%)44.961.90.004
 Obstetrical aspiration (%)5.63

Characteristics of neonates
 Sex ratio (% male)47.248.30.85
  Mean birthweight (g) (±SD)3388 (±549)3329 (±476)0.33
<10th perc. (%)19.113.8
 BW ≥10th perc. ≤ 90th perc. (%)67.477.6
 BW >90th perc. (%)13.58.60.15
 Apgar at 1 min ≤3 (%)51.71.1<0.0001
 Apgar at 5 min ≤5 (%)32.50.0<0.0001
 Tracheal aspiration at birth (%)80.98.2<0.0001

First care: <0.0001
 Pediatrician (%)73.428.5
 Midwife (%)23.671.5

CS: Cesarean section, IUGR: Intrauterine growth restriction, GBS: Group B Streptococcus, PROM: prolonged rupture of membranes (>12 hours), BW: birth weight.

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