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International Journal of Pediatrics
Volume 2014, Article ID 513460, 7 pages
http://dx.doi.org/10.1155/2014/513460
Clinical Study

Lipid Profile and Correlation to Cardiac Risk Factors and Cardiovascular Function in Type 1 Adolescent Diabetics from a Developing Country

1Department of Paediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, Bahadur Shah Zafar Marg, New Delhi 110002, India
2Department of Biochemistry, G. B. Pant Hospital, Jawahar Lal Nehru Marg, New Delhi 110002, India

Received 28 August 2013; Revised 14 April 2014; Accepted 14 April 2014; Published 12 May 2014

Academic Editor: F. J. Kaskel

Copyright © 2014 Aashima Dabas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The adverse role of dyslipidemia in predicting cardiovascular outcomes has not been elucidated extensively among type 1 diabetics in the literature. Methods. We assessed dyslipidemia and its correlation to other cardiac risk factors in adolescents with type 1 diabetes. Total thirty type 1 adolescent diabetics were evaluated for their metabolic profile, including serum lipids and echocardiography was performed. Results. The average age of the cohort was 14.3 ± 3.09 yr with disease duration of 5.35 ± 2.94 yr. The mean HbA1C was 8.01%. The mean serum cholesterol, LDL, HDL, and triglyceride were normal. Serum cholesterol was high in patients with longer disease duration ( , ), high systolic blood pressure ( , ), and elevated HbA1C > 8% ( , ). Higher lipid values were associated with poorer carotid artery distensibility ( ) and higher carotid artery intimomedial thickness (cIMT) ( for cholesterol and LDL). Hyperglycemia adversely affected ejection fractions, though serum lipids did not show any significant effect on left ventricular parameters. Conclusions. Dyslipidemia and hyperglycemia can serve as biomarkers for cardiovascular dysfunction in at-risk adolescents with type 1 diabetes. Carotid artery parameters are adjunctive tools which may be affected early in the course of macrovascular disease.