Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy
Table 3
Primary and secondary outcome variables for general criteria group.
Variable
WBTH ()
Non-WBTH ()
value
Primary outcomes (mean ± SD)
DOL enteral feeds started
0.39
DOL full enteral feeds reached
0.12
DOL full oral feeds reached
0.13
Secondary outcomes (%)
Never started enteral feeds
12.9
21.8
0.15
Never reached full enteral feeds
12.9
25.6
0.05
Never reached full oral feeds
25.7
42.3
0.03*
Death
15.9
23.4
0.26
GT
10
12.8
0.29
Combined death and GT
26
36.4
0.21
Discharged with gavage feeds
2.9
7.7
0.28
Combined death and discharged with gavage feeds
17.4
31.2
0.06
NEC+
2.9
5.1
0.68
ECMO
5.7
1.3
0.19
Elevated liver enzymes†
62.9
54.6
0.33
Elevated coagulation parameters∞
100
80.4
0.0001*
Days to hospital discharge or death
0.83
*Significance defined by P < 0.05.
+Grossly bloody stool (Bell’s stage IIA or greater). †Aspartate aminotransferase level >200 IU and alanine aminotransferase level >100 IU. ∞Prothrombin time >15.6 seconds and partial thromboplastin time >41.5 seconds.
