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International Journal of Pediatrics
Volume 2015 (2015), Article ID 856091, 7 pages
http://dx.doi.org/10.1155/2015/856091
Clinical Study

Enteral L-Arginine and Glutamine Supplementation for Prevention of NEC in Preterm Neonates

Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo 16088, Egypt

Received 14 December 2014; Accepted 2 March 2015

Academic Editor: Naveed Hussain

Copyright © 2015 M. S. El-Shimi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. M. Thompson and M. J. Bizzarro, “Necrotizing enterocolitis in newborns: pathogenesis, prevention and management,” Drugs, vol. 68, no. 9, pp. 1227–1238, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. E. S. Köhler, S. Sankaranarayanan, C. J. van Ginneken et al., “The human neonatal small intestine has the potential for arginine synthesis; developmental changes in the expression of arginine-synthesizing and -catabolizing enzymes,” BMC Developmental Biology, vol. 8, article 107, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Briassouli and G. Briassoulis, “Glutamine randomized studies in early life: the unsolved riddle of experimental and clinical studies,” Clinical and Developmental Immunology, vol. 2012, Article ID 749189, 17 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. H. J. Amin, S. A. Zamora, D. D. McMillan et al., “Arginine supplementation prevents necrotizing enterocolitis in the premature infant,” Journal of Pediatrics, vol. 140, no. 4, pp. 425–431, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Polycarpou, S. Zachaki, M. Tsolia et al., “Enteral L-arginine supplementation for prevention of necrotizing enterocolitis in very low birth weight neonates: a double-blind randomized pilot study of efficacy and safety,” Journal of Parenteral and Enteral Nutrition, vol. 37, no. 5, pp. 617–622, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. P. S. Shah and V. S. Shah, “Arginine supplementation for prevention of necrotising enterocolitis in preterm infants,” Cochrane Database of Systematic Reviews, no. 3, Article ID CD004339, 2007. View at Google Scholar · View at Scopus
  7. M. Holecek, “Side effects of long-term glutamine supplementation,” Journal of Parenteral & Enteral Nutrition, vol. 37, no. 5, pp. 607–616, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. P. S. Parimi and S. C. Kalhan, “Glutamine supplementation in the newborn infant,” Seminars in Fetal and Neonatal Medicine, vol. 12, no. 1, pp. 19–25, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Rao and G. Samak, “Role of glutamine in protection of intestinal epithelial tight junctions,” Journal of Epithelial Biology & Pharmacology, vol. 5, supplement 1-M7, pp. 47–54, 2012. View at Google Scholar
  10. J. L. Ballard, J. C. Khoury, K. Wedig, L. Wang, B. L. Eilers-Walsman, and R. Lipp, “New Ballard Score, expanded to include extremely premature infants,” Journal of Pediatrics, vol. 119, no. 3, pp. 417–423, 1991. View at Publisher · View at Google Scholar · View at Scopus
  11. B. A. Cobb, W. A. Carlo, and N. Ambalavanan, “Gastric residuals and their relationship to necrotizing enterocolitis in very low birth weight infants,” Pediatrics, vol. 113, no. 1, pp. 50–53, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. A. van den Berg, W. P. F. Fetter, E. A. M. Westerbeek, I. M. van der Vegt, H. R. A. van der Molen, and R. M. van Elburg, “The effect of glutamine-enriched enteral nutrition on intestinal permeability in very-low-birth-weight infants: a randomized controlled trial,” Journal of Parenteral and Enteral Nutrition, vol. 30, no. 5, pp. 408–414, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. M. J. Bell, J. L. Ternberg, R. D. Feigin et al., “Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging,” Annals of Surgery, vol. 187, no. 1, pp. 1–7, 1978. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Arnon and I. Litmanovitz, “Diagnostic tests in neonatal sepsis,” Current Opinion in Infectious Diseases, vol. 21, no. 3, pp. 223–227, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Tikanoja, O. Simell, A. L. Jarvenpaa, and N. C. R. Raiha, “Plasma animo acids in preterm infants after a feed of human milk or formula,” Journal of Pediatrics, vol. 101, no. 2, pp. 248–252, 1982. View at Publisher · View at Google Scholar · View at Scopus
  16. T.-C. Lin, Y.-R. Chen, E. Kensicki et al., “Resetting glutamine-dependent metabolism and oxygen consumption,” Autophagy, vol. 8, no. 10, pp. 1477–1493, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. K. L. Schnabl, J. E. van Aerde, A. B. R. Thomson, and M. T. Clandinin, “Necrotizing enterocolitis: a multifactorial disease with no cure,” World Journal of Gastroenterology, vol. 14, no. 14, pp. 2142–2161, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. H.-Y. Lin, J. H. Chang, M.-Y. Chung, and H.-C. Lin, “Prevention of necrotizing enterocolitis in preterm very low birth weight infants: is it feasible?” Journal of the Formosan Medical Association, vol. 20, no. 13, pp. 126–135, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Kul, S. Vurucu, E. Demirkaya et al., “Enteral glutamine and/or arginine supplementation have favorable effects on oxidative stress parameters in neonatal rat intestine,” Journal of Pediatric Gastroenterology & Nutrition, vol. 49, no. 1, pp. 85–89, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Morgan, L. Young, and W. McGuire, “Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants,” The Cochrane Database of Systematic Reviews, vol. 3, Article ID CD001241, 2013. View at Google Scholar · View at Scopus
  21. E. M. Fallon, D. Nehra, A. K. Potemkin et al., “A.S.P.E.N. clinical guidelines: nutrition support of neonatal patients at risk for necrotizing enterocolitis,” Journal of Parenteral & Enteral Nutrition, vol. 36, no. 5, pp. 506–523, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Srinivasan, A. Amin, R. S. Pildes, L. D. Lilien, and R. Matalon, “Plasma amino acid patterns in very low birth weight infants during parenteral nutrition,” The Indian Journal of Pediatrics, vol. 57, no. 1, pp. 93–97, 1990. View at Publisher · View at Google Scholar · View at Scopus
  23. J. M. Lacey, J. B. Crouch, K. Benfell et al., “The effects of glutamine-supplemented parenteral nutrition in premature infants,” Journal of Parenteral and Enteral Nutrition, vol. 20, no. 1, pp. 74–80, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Bober-Olesińska and M. K. Kornacka, “Effects of glutamine supplemented parenteral nutrition on the incidence of necrotizing enterocolitis, nosocomial sepsis and length of hospital stay in very low birth weight infants,” Medycyna Wieku Rozwojowego, vol. 9, no. 3, part 1, pp. 325–333, 2005 (Polish). View at Google Scholar · View at Scopus
  25. S. Sevastiadou, A. Malamitsi-Puchner, C. Costalos et al., “The impact of oral glutamine supplementation on the intestinal permeability and incidence of necrotizing enterocolitis/septicemia in premature neonates,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 24, no. 10, pp. 1294–1300, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Neu, V. DeMarco, and N. Li, “Glutamine: clinical applications and mechanisms of action,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 5, no. 1, pp. 69–75, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Vaughn, P. Thomas, R. Clark, and J. Neu, “Enteral glutamine supplementation and morbidity in low birth weight infants,” Journal of Pediatrics, vol. 142, no. 6, pp. 662–668, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. J.-C. Preiser, D. Peres-Bota, P. Eisendrath, J.-L. Vincent, and A. Van Gossum, “Gut mucosal and plasma concentrations of glutamine: a comparison between two enriched enteral feeding solutions in critically ill patients,” Nutrition Journal, vol. 2, article 13, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. C. Luiking, M. Poeze, G. Ramsay, and N. E. P. Deutz, “The role of arginine in infection and sepsis,” Journal of Parenteral and Enteral Nutrition, vol. 29, no. 1, supplement, pp. S70–S74, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. T. R. Tubman, S. W. Thompson, and W. McGuire, “Glutamine supplementation to prevent morbidity and mortality in preterm infants,” Cochrane Database of Systematic Reviews, vol. 23, no. 1, Article ID CD001457, 2008. View at Google Scholar · View at Scopus