Research Article
Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study
Table 1
Characteristics of preterm infants in this study
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| Variables | Early caffeine (1-2 DOL) | Late caffeine (3–7 DOL) | Very late caffeine (≥8 DOL) | p value |
| | 85 | 46 | 19 | | Gestational age, wk | 26.34 ± 1.84 | 26.41 ± 1.80 | 25.94 ± 2.01 | | Birth weight, g | 891.78 ± 227.50 | 909.13 ± 243.92 | 835.61 ± 188.70 | | Sex (female/male) | 38/47 | 28/18 | 9/10 | | (44.7%, 55.3%) | (60.9%, 39.1%) | (47.4%, 52.6%) | Birth history (multiple birth) | 14 (16.5%) | 8 (17.4%) | 1 (5.3%) | | Vaginal delivery | 46 (54.1%) | 16 (34.8%) | 8 (42.1%) | | Chorioamnionitis | 11 (12.9%) | 8 (17.4%) | 1 (5.3%) | | Apgar, 1 min | 5.41 ± 2.26 | 5.61 ± 2.10 | 5.11 ± 2.13 | | Apgar, 5 min | 7.29 ± 1.45 | 7.31 ± 1.58 | 7.42 ± 1.17 | | Surfactant | 67 (78.8%) | 35 (76.1%) | 15 (78.9%) | | Ethnicity African American and Hispanic Black | 95% | 95% | 95% | |
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This study includes preterm infants with GA = 23–29 weeks and BW < 1500 g. DOL, days of life.
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