Research Article

Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study

Table 1

Characteristics of preterm infants in this study.

VariablesEarly caffeine
(1-2 DOL)
Late caffeine
(3–7 DOL)
Very late caffeine
(≥8 DOL)
p value

854619
Gestational age, wk26.34 ± 1.8426.41 ± 1.8025.94 ± 2.01
Birth weight, g891.78 ± 227.50909.13 ± 243.92835.61 ± 188.70
Sex (female/male)38/4728/189/10
(44.7%, 55.3%)(60.9%, 39.1%)(47.4%, 52.6%)
Birth history (multiple birth)14 (16.5%)8 (17.4%)1 (5.3%)
Vaginal delivery46 (54.1%)16 (34.8%)8 (42.1%)
Chorioamnionitis11 (12.9%)8 (17.4%)1 (5.3%)
Apgar, 1 min5.41 ± 2.265.61 ± 2.105.11 ± 2.13
Apgar, 5 min7.29 ± 1.457.31 ± 1.587.42 ± 1.17
Surfactant 67 (78.8%)35 (76.1%)15 (78.9%)
Ethnicity
African American and Hispanic Black
95% 95%95%

This study includes preterm infants with GA = 23–29 weeks and BW < 1500 g.
DOL, days of life.