|
| Cases |
| Inclusion criteria: |
| Children less than 5 years old |
| Presence of acute, moderate-to-severe diarrhea and/or vomiting within the past 10 days. The World Health Organization defines diarrhea as 3 or more episodes of loose or liquid stools |
| within 24 hours |
| Children who are not part of this study as a case (not previously recorded to have diarrhea within the last 60 days) |
| Diarrhea is moderate to severe and must meet at least one of the following criteria: |
| (i) Sunken eyes, confirmed by parent/caretaker |
| (ii) Loss of skin turgor by skin pinch (≤2 s slow or >2 very slow) |
| (iii) Intravenous rehydration prescribed or administered |
| (iv) Dysentery (1 or more bloody stools) |
| (v) Evaluated in the emergency department or admitted to the hospital for diarrhea |
| Children will still be eligible for enrollment even if they have received antibiotics within the last 14 days |
| Exclusion criteria: |
| Children older than 60 months of age |
| Children who reside outside of the metropolitan area of Bucaramanga, Colombia |
| Presence of chronic diarrhea (>10 days) or other comorbid conditions such as Crohn’s disease or ulcerative colitis |
|
| Controls |
| Inclusion criteria: |
| Children less than 5 years old |
| Child who resides within the metropolitan area of Bucaramanga, Colombia |
| Absence of diarrhea or vomiting within the past 10 days |
| Matched to cases for age. Age matching is ±2 months for 0–11 months, ±4 months for 12–59 months (can not exceed the stratum boundaries of the case) |
| Exclusion criteria: |
| Children older than 60 months of age |
| Child who does not reside within the Metropolitan area of Bucaramanga, Colombia |
| Presence of acute diarrhea, as defined by the WHO, in the previous 7 days (regardless of whether they develop diarrhea after enrollment) |
| Presence of chronic diarrhea (>10 days) or other comorbid conditions such as Crohn’s disease or ulcerative colitis |
|
