International Journal of Pediatrics / 2018 / Article / Tab 2

Research Article

Growth and Neurodevelopmental Outcome in Preterm LBW Infants with Sepsis in India: A Prospective Cohort

Table 2

(a) Comparison of basic variables between both studied groups

VariableSepsisNo sepsis value

Gestational age,
mean (wk)
30.275 (SD ± 2.20)31.22 (SD ± 1.86)<0.02
Birth WT, median (gms)1706 (IQR 1560–1880)2060 (IQR 1650–2360)<0.01
Birth OFC, median (cm)27.7 (IQR 26–30)29.57 (IQR 27–31)<0.01
Birth length, median (cm)36.9 (IQR 34–39)38.48 (IQR 35–40)<0.01
Male23 (57.5%)25 (46.2%)0.28

WT: weight; OFC: occipitofrontal circumference.
(b) Comparison of antenatal events between both studied groups

VariableSepsis ()No sepsis () value

Singleton32 (80%)45 (83.3%)0.90
Primi19 (47.5%)25 (46.2%)0.82
AGA21 (52.7%)28 (51.85%)0.95
PIH27 (67.5%)34 (62.9%)0.64
Diabetes6 (15%)5 (9.2%)0.41
Hypothyroid6 (15%)10 (18.51%)0.70
PPROM11 (27.5%)08 (14.81%)0.13
Preterm labor6 (15%)15 (27.7%)0.14
Oligohydramnios13 (32.5%)14 (25.92%)0.49
APH1 (2.5%)4 (7.4%)0.29
Steroid covered36 (90%)45 (83.3%)0.35
LSCS35 (87.5%)46 (85.18%)0.75
Resuscitation at birth12 (30%)4 (7.4%)<0.001

AGA: appropriate for gestational age; PIH: pregnancy induced hypertension; PPROM: preterm prelabor rupture of membranes; APH; antepartum hemorrhage; LSCS: lower segment caesarian section.
(c) Comparison of NICU morbidities between both studied groups

VariableSepsis ()No sepsis () value

HMD21 (52.5%)20 (37.03%)0.13
CPAP26 (65%)28 (51.8%)0.30
Surfactant22 (55%)15 (27.7%)0.007
SIMV13 (32.5%)5 (9.2%)<0.001
HFO6 (15%)5 (9.2%)0.39
NEC16 (40%)3 (5.5%)<0.001
Shock35 (87.5%)13 (24.07%)<0.001
Exchange transfusion19 (47.5%)00<0.001
Seizure6 (15%)2 (3.7%)0.05
Hypoglycemia8 (20%)1 (1.8%)<0.001
Apnea13 (32.5%)1 (1.8%)<0.001
Anemia transfusion8 (20%)6 (11.11%)0.22
PDA9 (22.5%)2 (3.7%)0.004
BPD7 (17.5%)3 (5.55%)0.06

BPD: bronchopulmonary dysplasia; PDA: Patent Ductus Arteriosus; NEC: necrotizing enterocolitis; HFO: high frequency oscillatory ventilation; SIMV: synchronized intermittent mandatory ventilation; HMD: hyaline membrane disease; CPAP: continuous positive airway pressure.
(d) Comparison of NICU variables between both studied groups

VariableSepsis ()No sepsis () value

Discharge WT, mean (gms)1902 (SD ± 90.55)2097 (SD ± 137)0.01
Discharge OFC, mean (cm)28.95 (SD ± 2.366)30.07 (SD ± 1.078)0.01
Discharge LT, mean (cm)38.8 (SD ± 1.70)39.65 (SD ± 1.90)0.01
Days to full feeds, mean (days)7.6 (SD ± 2.92)8.1 (SD ± 3.30)0.39
Hospital stay, mean16.8 (SD ± 6.31)18.48 (SD ± 8.64)0.32
BERA (abnormal)10 (25%)2 (3.7%)0.001
ROP10 (25%)7 (12.9%)0.001
NSG (abnormal)25 (62.5%)5 (9.2%)<0.001

WT: weight; OFC: occipitofrontal circumference; LT: length; BERA: brainstem evoked response audiometry; ROP: Retinopathy of Prematurity; NSG: Neurosonogram.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.